Association between polymorphisms in connexin 40 gene (Cx40) and risk of atrial fibrillation: a meta-analysis based on 3,452 subjects.

IF 2 4区医学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Biomarkers Pub Date : 2023-09-01 Epub Date: 2023-07-13 DOI:10.1080/1354750X.2023.2227361

Zheng Lian, Zheng Ma, Zhi-Li Zhang, Pei-Lin Liu, Guo-Yong Zhang, Cai-Xia Guo

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引用次数: 0

Abstract

Introduction: Atrial fibrillation (AF) is a common cardiac arrhythmia that is associated with heart failure and stroke, leading sometimes to death. But the pathogenesis of AF remains unclear. Numerous studies have investigated whether the connexin 40 (Cx40) polymorphisms influences the risk of AF, but the results are controversial.

Methods: We searched English and Chinese databases and calculated the odds ratio (OR) and 95% confidence interval (CI) to examine the existence of genetic associations between the Cx40 polymorphisms and the risk of AF. All relevant studies were screened and meta-analyzed using Review Manager 5.0.

Results: A total of 12 studies, including 10 studies for -44 polymorphism (rs35594137) and 4 studies for -26 polymorphism (rs10465885), were identified for the meta-analysis. For -44 polymorphism, the results showed a significantly increased risk of AF in the five genetic models in the overall analysis. Furthermore, in subgroup analysis, increased AF risks were also observed in Asian and non-Asian populations. For -26 polymorphism, the overall OR revealed an increased risk of AF in dominant model. In subgroup analysis, increased AF risk was only found in recessive genetic model of the Asian population.

Conclusions: The Cx40 polymorphisms were positively associated with AF in both populations, especially on -44 polymorphism.

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连接蛋白40基因（Cx40）多态性与心房颤动风险的相关性：一项基于3452名受试者的荟萃分析。

引言：心房颤动（AF）是一种常见的心律失常，与心力衰竭和中风有关，有时会导致死亡。但房颤的发病机制尚不清楚。许多研究已经调查了连接蛋白40（Cx40）多态性是否会影响房颤的风险，但结果存在争议。方法：我们检索英文和中文数据库，计算比值比（OR）和95%置信区间（CI），以检查Cx40多态性与AF风险之间是否存在遗传关联。使用Review Manager 5.0对所有相关研究进行筛选和荟萃分析。结果：共有12项研究，包括10项-44多态性研究（rs35594137）和4项-26多态性的研究（rs10465885）。对于-44多态性，在总体分析中，结果显示五个遗传模型中患AF的风险显著增加。此外，在亚组分析中，亚洲和非亚洲人群的房颤风险也有所增加。对于-26多态性，总体OR显示显性模型中AF的风险增加。在亚组分析中，AF风险的增加仅在亚洲人群的隐性遗传模型中发现。结论：Cx40多态性在两个人群中均与AF呈正相关，尤其是44多态性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomarkers 医学-毒理学

CiteScore

5.00

自引率

3.80%

发文量

140

审稿时长

3 months

期刊介绍： The journal Biomarkers brings together all aspects of the rapidly growing field of biomarker research, encompassing their various uses and applications in one essential source. Biomarkers provides a vital forum for the exchange of ideas and concepts in all areas of biomarker research. High quality papers in four main areas are accepted and manuscripts describing novel biomarkers and their subsequent validation are especially encouraged: • Biomarkers of disease • Biomarkers of exposure • Biomarkers of response • Biomarkers of susceptibility Manuscripts can describe biomarkers measured in humans or other animals in vivo or in vitro. Biomarkers will consider publishing negative data from studies of biomarkers of susceptibility in human populations.