Effect of Sodium Bicarbonate Ringer's Solution on Intraoperative Blood Gas Analysis and Postoperative Recovery Time in Liver Transplantation: A Single-Center Retrospective Study.
Haiyan Xian, Qiuwen Xie, Ke Qin, Xiangfei Ma, Xueke Du
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引用次数: 0
Abstract
BACKGROUND Sodium bicarbonate Ringer's solution (BRS) is the latest generation of balanced crystal solutions. BRS does not increase the liver burden, but its impact in liver transplantation is unclear. The aim of this study was to investigate the effect of BRS as a fluid therapy on intraoperative blood gas analysis and postoperative recovery time in orthotopic liver transplantation (LT) patients. MATERIAL AND METHODS The study included 101 patients who received classical in situ liver transplantation at the Second Affiliated Hospital of Guangxi Medical University from November 2019 to January 2022. The patients were divided into 2 groups according to the intraoperative fluid infusion: the BRS group and the sodium lactate Ringer's solution group (LRS group). Intraoperative blood gas analysis, including pH, base excess (BE), bicarbonate, and lactic acid levels of radial artery blood, were collected after induction (T0), 30 min before opening (T1), 30 min after no liver period (T2), 30 min after opening (T3), and at the end of the operation (T4). Postoperative ICU catheter time, ICU stay time, and total hospitalization days were also recorded and compared between the 2 groups. RESULTS Lactic acid levels were decreased significantly at T3 in the BRS group (P<0.05). ICU catheter time, ICU hospitalization days, and total hospitalization days were significantly shorter in the BRS group (P<0.05). CONCLUSIONS BRS can decrease the lactic acid level at 30 min after opening, reducing the postoperative recovery time. BRS is more effective than LRS in liver transplantation.
碳酸氢钠林格溶液(BRS)是最新一代的平衡晶体溶液。BRS不增加肝脏负担，但其对肝移植的影响尚不清楚。本研究的目的是探讨BRS作为液体疗法对原位肝移植(LT)患者术中血气分析和术后恢复时间的影响。材料与方法本研究纳入了2019年11月至2022年1月在广西医科大学第二附属医院接受经典原位肝移植的101例患者。根据术中输液情况将患者分为两组:BRS组和乳酸钠林格液组(LRS组)。取术中血气分析，包括诱导后(T0)、开放前30 min (T1)、无肝期后30 min (T2)、开放后30 min (T3)、手术结束时(T4)桡动脉血pH、碱过量(BE)、碳酸氢盐、乳酸水平。记录两组患者术后ICU置管时间、ICU住院时间、总住院天数。结果BRS组大鼠T3时乳酸水平显著降低(P
期刊介绍：
Annals of Transplantation is one of the fast-developing journals open to all scientists and fields of transplant medicine and related research. The journal is published quarterly and provides extensive coverage of the most important advances in transplantation.
Using an electronic on-line submission and peer review tracking system, Annals of Transplantation is committed to rapid review and publication. The average time to first decision is around 3-4 weeks. Time to publication of accepted manuscripts continues to be shortened, with the Editorial team committed to a goal of 3 months from acceptance to publication.
Expert reseachers and clinicians from around the world contribute original Articles, Review Papers, Case Reports and Special Reports in every pertinent specialty, providing a lot of arguments for discussion of exciting developments and controversies in the field.
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