Extracellular vesicles as mediators of cell-cell communication in ovarian cancer and beyond – A lipids focus

IF 9.3 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cytokine & Growth Factor Reviews Pub Date : 2023-10-01 DOI:10.1016/j.cytogfr.2023.06.004

Shikha Rani , Andrew Lai , Soumya Nair , Shayna Sharma , Aase Handberg , Flavio Carrion , Andreas Möller , Carlos Salomon

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引用次数: 4

Abstract

Extracellular vesicles (EVs) are messengers that carry information in the form of proteins, lipids, and nucleic acids and are not only essential for intercellular communication but also play a critical role in the progression of various pathologies, including ovarian cancer. There has been recent substantial research characterising EV cargo, specifically, the lipid profile of EVs. Lipids are involved in formation and cargo sorting of EVs, their release and cellular uptake. Numerous lipidomic studies demonstrated the enrichment of specific classes of lipids in EVs derived from cancer cells suggesting that the EV associated lipids can potentially be employed as minimally invasive biomarkers for early diagnosis of various malignancies, including ovarian cancer. In this review, we aim to provide a general overview of the heterogeneity of EV, biogenesis, their lipid content, and function in cancer progression focussing on ovarian cancer.

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细胞外小泡作为细胞间通讯的介质在卵巢癌症及其后-脂质焦点。

细胞外小泡（EVs）是以蛋白质、脂质和核酸的形式携带信息的信使，不仅对细胞间通讯至关重要，而且在包括卵巢癌症在内的各种病理学的进展中发挥着关键作用。最近对电动汽车货物进行了大量研究，特别是电动汽车的脂质状况。脂质参与电动汽车的形成和货物分拣、释放和细胞吸收。许多脂质组学研究表明，在来源于癌症细胞的EV中富集了特定类别的脂质，这表明EV相关的脂质可能被用作各种恶性肿瘤（包括癌症）的微创生物标志物。在这篇综述中，我们的目的是提供EV的异质性、生物发生、其脂质含量和功能在癌症进展中的一般概述，重点是卵巢癌症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cytokine & Growth Factor Reviews 生物-生化与分子生物学

CiteScore

21.10

自引率

1.50%

发文量

审稿时长

22 days

期刊介绍： Cytokine & Growth Factor Reviews is a leading publication that focuses on the dynamic fields of growth factor and cytokine research. Our journal offers a platform for authors to disseminate thought-provoking articles such as critical reviews, state-of-the-art reviews, letters to the editor, and meeting reviews. We aim to cover important breakthroughs in these rapidly evolving areas, providing valuable insights into the multidisciplinary significance of cytokines and growth factors. Our journal spans various domains including signal transduction, cell growth and differentiation, embryonic development, immunology, tumorigenesis, and clinical medicine. By publishing cutting-edge research and analysis, we aim to influence the way researchers and experts perceive and understand growth factors and cytokines. We encourage novel expressions of ideas and innovative approaches to organizing content, fostering a stimulating environment for knowledge exchange and scientific advancement.