Changes in tidal breathing biomarkers as indicators of treatment response in AECOPD patients in an acute care setting

IF 2.5 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Advances in medical sciences Pub Date : 2023-09-01 DOI:10.1016/j.advms.2023.04.001

Tess Nuñez Quiroga , Nadav Bachar , Wieland Voigt , Noy Danino , Inbal Shafran , Ronit Shtrichman , Gregory Shuster , Nina Lambrecht , Stephan Eisenmann

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引用次数: 0

Abstract

Purpose

Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is a complication of COPD that typically necessitates intensified treatment and hospitalization. It is linked to higher morbidity, mortality and healthcare spending. Assessment of therapy response for AECOPD is difficult due to the variability of symptoms and limitations in current measures. Hence, there is a need for new biomarkers to aid in the management of AECOPD in acute care settings.

Materials and methods

Fifteen hospitalized AECOPD patients (GOLD 3–4) were enrolled in this study. Treatment response was assessed daily through clinical evaluations and by monitoring tidal breathing biomarkers (respiratory rate [RR], expiratory time [T_ex], inspiratory time [T_in], expiratory pause [T_rst], total breath time [T_tot]), using a novel, wearable nanosensor-based device (SenseGuard™).

Results

Patients who showed significant clinical improvement had substantial changes in ΔT_ex/T_tot (+14%), ΔT_rst/T_tot (−18%), and ΔT_in/T_ex (+0.09), whereas patients who showed mild or no clinical improvement had smaller changes (+5%, +3%, and −0.03, respectively). Linear regression between change in physician's assessment score and the median change in tidal breathing parameters was significant for T_in/T_ex (R² = 0.449, ∗p = 0.017), T_ex/T_tot (R² = 0.556, ∗p = 0.005) and T_rst/T_tot (R² = 0.446, ∗p = 0.018), while no significant regression was observed for RR, T_in/(T_rst + T_ex) and T_in/T_tot.

Conclusions

Our study demonstrates the potential of the SenseGuard™ to monitor treatment response in AECOPD patients by measuring changes in tidal breathing biomarkers, which were shown to be associated with significant changes in the patients' respiratory condition as evaluated by physicians. However, further large-scale clinical studies are needed to confirm these findings.

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在急性护理环境中，潮汐呼吸生物标志物作为AECOPD患者治疗反应指标的变化

目的慢性阻塞性肺病（AECOPD）急性加重是COPD的一种并发症，通常需要加强治疗和住院治疗。它与更高的发病率、死亡率和医疗支出有关。由于症状的可变性和当前测量的局限性，评估AECOPD的治疗反应是困难的。因此，需要新的生物标志物来帮助在急性护理环境中管理AECOPD。材料和方法本研究纳入了五名住院的AECOPD患者（GOLD 3-4）。每天通过临床评估和监测潮汐呼吸生物标志物（呼吸频率[RR]、呼气时间[Tex]、吸气时间[Tin]、呼气暂停[Trst]、总呼吸时间[Ttot]），使用新型可穿戴纳米传感器设备（SenseGuard™).结果表现出显著临床改善的患者ΔTex/Ttot（+14%）、ΔTrst/Ttot（-18%）和ΔTin/Tex（+0.09）有显著变化，而表现出轻微或无临床改善的病人变化较小（分别为+5%、+3%和-0.03）。Tin/Tex的医师评估得分变化与潮气呼吸参数中位数变化之间的线性回归显著（R2=0.449，*p=0.017）、Tex/Ttot（R2=0.556，*p=0.005）和Trst/Ttot（R2=0.446，*p=0.018），而RR、Tin/（Trst）没有观察到显著的回归+Tex）和Tin/Ttot。结论我们的研究证明了SenseGuard的潜力™ 通过测量潮汐呼吸生物标志物的变化来监测AECOPD患者的治疗反应，医生评估这些生物标志物与患者呼吸状况的显著变化有关。然而，还需要进一步的大规模临床研究来证实这些发现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advances in medical sciences 医学-医学：研究与实验

CiteScore

5.00

自引率

0.00%

发文量

审稿时长

25 days

期刊介绍： Advances in Medical Sciences is an international, peer-reviewed journal that welcomes original research articles and reviews on current advances in life sciences, preclinical and clinical medicine, and related disciplines. The Journal’s primary aim is to make every effort to contribute to progress in medical sciences. The strive is to bridge laboratory and clinical settings with cutting edge research findings and new developments. Advances in Medical Sciences publishes articles which bring novel insights into diagnostic and molecular imaging, offering essential prior knowledge for diagnosis and treatment indispensable in all areas of medical sciences. It also publishes articles on pathological sciences giving foundation knowledge on the overall study of human diseases. Through its publications Advances in Medical Sciences also stresses the importance of pharmaceutical sciences as a rapidly and ever expanding area of research on drug design, development, action and evaluation contributing significantly to a variety of scientific disciplines. The journal welcomes submissions from the following disciplines: General and internal medicine, Cancer research, Genetics, Endocrinology, Gastroenterology, Cardiology and Cardiovascular Medicine, Immunology and Allergy, Pathology and Forensic Medicine, Cell and molecular Biology, Haematology, Biochemistry, Clinical and Experimental Pathology.