The Remarkable Outer Hair Cell: Proceedings of a Symposium in Honour of W. E. Brownell.

IF 2.4 3区医学 Q3 NEUROSCIENCES

Jaro-Journal of the Association for Research in Otolaryngology Pub Date : 2023-04-01 Epub Date: 2023-01-17 DOI:10.1007/s10162-022-00852-4

Jonathan F Ashmore, John S Oghalai, James B Dewey, Elizabeth S Olson, Clark E Strimbu, Yi Wang, Christopher A Shera, Alessandro Altoè, Carolina Abdala, Ana B Elgoyhen, Ruth Anne Eatock, Robert M Raphael

引用次数: 0

Abstract

In 1985, Bill Brownell and colleagues published the remarkable observation that cochlear outer hair cells (OHCs) express voltage-driven mechanical motion: electromotility. They proposed OHC electromotility as the mechanism for the elusive "cochlear amplifier" required to explain the sensitivity of mammalian hearing. The finding and hypothesis stimulated an explosion of experiments that have transformed our understanding of cochlear mechanics and physiology, the evolution of hair cell structure and function, and audiology. Here, we bring together examples of current research that illustrate the continuing impact of the discovery of OHC electromotility.

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了不起的外毛细胞：纪念 W. E. Brownell 研讨会论文集》。

1985 年，比尔-布朗内尔（Bill Brownell）及其同事发表了一项引人注目的观察结果，即耳蜗外毛细胞（OHC）表现出电压驱动的机械运动：电动运动。他们提出，耳蜗外毛细胞的电运动是难以捉摸的 "耳蜗放大器 "的机制，而 "耳蜗放大器 "是解释哺乳动物听觉灵敏度所必需的。这一发现和假设激发了大量实验，改变了我们对耳蜗力学和生理学、毛细胞结构和功能进化以及听力学的理解。在此，我们汇集了当前研究的一些实例，这些实例说明了耳蜗细胞电迁移发现的持续影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Jaro-Journal of the Association for Research in Otolaryngology 医学-耳鼻喉科学

CiteScore

4.10

自引率

12.50%

发文量

审稿时长

6-12 weeks

期刊介绍： JARO is a peer-reviewed journal that publishes research findings from disciplines related to otolaryngology and communications sciences, including hearing, balance, speech and voice. JARO welcomes submissions describing experimental research that investigates the mechanisms underlying problems of basic and/or clinical significance. Authors are encouraged to familiarize themselves with the kinds of papers carried by JARO by looking at past issues. Clinical case studies and pharmaceutical screens are not likely to be considered unless they reveal underlying mechanisms. Methods papers are not encouraged unless they include significant new findings as well. Reviews will be published at the discretion of the editorial board; consult the editor-in-chief before submitting.