The impact of obesity on lung function measurements and respiratory disease: A Mendelian randomization study

IF 1 4区生物学 Q4 GENETICS & HEREDITY

Annals of Human Genetics Pub Date : 2023-04-03 DOI:10.1111/ahg.12506

Jiayan Liu, Hanfei Xu, L Adrienne Cupples, George T. O’ Connor, Ching-Ti Liu

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引用次数: 0

Abstract

Introduction

Observational studies have shown that body mass index (BMI) and waist-to-hip ratio (WHR) are both inversely associated with lung function, as assessed by forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1). However, observational data are susceptible to confounding and reverse causation.

Methods

We selected genetic instruments based on their relevant large-scale genome-wide association studies. Summary statistics of lung function and asthma came from the UK Biobank and SpiroMeta Consortium meta-analysis (n = 400,102). After examining pleiotropy and removing outliers, we applied inverse-variance weighting to estimate the causal association of BMI and BMI-adjusted WHR (WHRadjBMI) with FVC, FEV1, FEV1/FVC, and asthma. Sensitivity analyses were performed using weighted median, MR-Egger, and MRlap methods.

Results

We found that BMI was inversely associated with FVC (effect estimate, −0.167; 95% confidence interval (CI), −0.203 to −0.130) and FEV1 (effect estimate, −0.111; 95%CI, −0.149 to −0.074). Higher BMI was associated with higher FEV1/FVC (effect estimate, 0.079; 95%CI, 0.049 to 0.110) but was not significantly associated with asthma. WHRadjBMI was inversely associated with FVC (effect estimate, −0.132; 95%CI, −0.180 to −0.084) but has no significant association with FEV1. Higher WHR was associated with higher FEV1/FVC (effect estimate, 0.181; 95%CI, 0.130 to 0.232) and with increased risk of asthma (effect estimate, 0.027; 95%CI, 0.001 to 0.053).

Conclusion

We found significant evidence that increased BMI is suggested to be causally related to decreased FVC and FEV1, and increased BMI-adjusted WHR could lead to lower FVC value and higher risk of asthma. Higher BMI and BMI-adjusted WHR were suggested to be causally associated with higher FEV1/FVC.

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肥胖对肺功能测量和呼吸系统疾病的影响:一项孟德尔随机研究

观察性研究表明，通过用力肺活量(FVC)和1s用力呼气量(FEV1)评估，体重指数(BMI)和腰臀比(WHR)均与肺功能呈负相关。然而，观测数据容易受到混淆和反向因果关系的影响。方法基于相关的大规模全基因组关联研究选择遗传工具。肺功能和哮喘的汇总统计数据来自UK Biobank和SpiroMeta Consortium荟萃分析(n = 400,102)。在检查了多效性并去除异常值后，我们应用反方差加权来估计BMI和BMI调整的WHR (WHRadjBMI)与FVC、FEV1、FEV1/FVC和哮喘之间的因果关系。采用加权中位数、MR-Egger和MRlap方法进行敏感性分析。结果我们发现BMI与FVC呈负相关(效应估计，- 0.167;95%置信区间(CI)，−0.203至−0.130)和FEV1(效应估计，−0.111;95%CI， - 0.149 ~ - 0.074)。较高的BMI与较高的FEV1/FVC相关(效应估计，0.079;95%CI, 0.049 ~ 0.110)，但与哮喘无显著相关性。WHRadjBMI与FVC呈负相关(效应估计为- 0.132;95%CI，−0.180 ~−0.084)，但与FEV1无显著相关性。高腰重比与较高的FEV1/FVC相关(效应估计，0.181;95%CI, 0.130 ~ 0.232)，哮喘风险增加(效应估计，0.027;95%CI, 0.001 ~ 0.053)。结论BMI升高与FVC、FEV1的降低存在显著的因果关系，BMI调整后的WHR升高可导致FVC值降低，哮喘风险增加。较高的BMI和BMI调整后的WHR与较高的FEV1/FVC有因果关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Human Genetics 生物-遗传学

CiteScore

4.20

自引率

0.00%

发文量

审稿时长

3 months

期刊介绍： Annals of Human Genetics publishes material directly concerned with human genetics or the application of scientific principles and techniques to any aspect of human inheritance. Papers that describe work on other species that may be relevant to human genetics will also be considered. Mathematical models should include examples of application to data where possible. Authors are welcome to submit Supporting Information, such as data sets or additional figures or tables, that will not be published in the print edition of the journal, but which will be viewable via the online edition and stored on the website.