Effect of infiltrating immune cells in tumor microenvironment on metastasis of hepatocellular carcinoma.

IF 4.9 2区医学 Q2 CELL BIOLOGY

Cellular Oncology Pub Date : 2023-12-01 Epub Date: 2023-07-06 DOI:10.1007/s13402-023-00841-6

Yiwen Chen, Yuhang Zhou, Ziyang Yan, Peilin Tong, Qiang Xia, Kang He

引用次数: 1

Abstract

Hepatocellular carcinoma (HCC) is one of the most lethal and prevalent human malignancies, leading to poor prognosis due to its high recurrence and metastasis rates. In recent years it has become increasingly evident that the tumor microenvironment (TME) plays an important role in tumor progression and metastasis. Tumor microenvironment (TME) refers to the complex tissue environment of tumor occurrence and development. Here, we summarize the development of HCC and the role of cellular and non-cellular components of the TME in the metastasis HCC, with particular reference to tumor-infiltrating immune cells. We also discuss some of the possible therapeutic targets for the TME and the future prospectives of this evolving field. SIGNIFICANCE: This review provides a comprehensive analysis of the role of the infiltrating immune cells in TME in the metastasis of HCC and highlights the future outlook for targeted therapy of the TME in the context of recent experiments revealing a number of therapeutic targets targeting the TME.

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肿瘤微环境中浸润性免疫细胞对肝癌转移的影响。

肝细胞癌(HCC)是最致命和最常见的人类恶性肿瘤之一，由于其高复发和转移率，导致预后不良。近年来，肿瘤微环境(tumor microenvironment, TME)在肿瘤进展和转移过程中起着重要作用的研究越来越明显。肿瘤微环境(Tumor microenvironment, TME)是指肿瘤发生发展的复杂组织环境。在这里，我们总结了HCC的发展以及TME的细胞和非细胞成分在HCC转移中的作用，特别是肿瘤浸润性免疫细胞。我们还讨论了TME的一些可能的治疗靶点以及这一不断发展的领域的未来前景。意义:本综述全面分析了TME浸润性免疫细胞在HCC转移中的作用，并在最近的实验中揭示了一些针对TME的治疗靶点，强调了TME靶向治疗的未来前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cellular Oncology ONCOLOGY-CELL BIOLOGY

CiteScore

10.30

自引率

1.50%

发文量

审稿时长

12 months

期刊介绍： The Official Journal of the International Society for Cellular Oncology Focuses on translational research Addresses the conversion of cell biology to clinical applications Cellular Oncology publishes scientific contributions from various biomedical and clinical disciplines involved in basic and translational cancer research on the cell and tissue level, technical and bioinformatics developments in this area, and clinical applications. This includes a variety of fields like genome technology, micro-arrays and other high-throughput techniques, genomic instability, SNP, DNA methylation, signaling pathways, DNA organization, (sub)microscopic imaging, proteomics, bioinformatics, functional effects of genomics, drug design and development, molecular diagnostics and targeted cancer therapies, genotype-phenotype interactions. A major goal is to translate the latest developments in these fields from the research laboratory into routine patient management. To this end Cellular Oncology forms a platform of scientific information exchange between molecular biologists and geneticists, technical developers, pathologists, (medical) oncologists and other clinicians involved in the management of cancer patients. In vitro studies are preferentially supported by validations in tumor tissue with clinicopathological associations.