Control of Tissue Development by Morphogens.

IF 11.4 1区 生物学 Q1 CELL BIOLOGY
Anna Kicheva, James Briscoe
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引用次数: 3

Abstract

Intercellular signaling molecules, known as morphogens, act at a long range in developing tissues to provide spatial information and control properties such as cell fate and tissue growth. The production, transport, and removal of morphogens shape their concentration profiles in time and space. Downstream signaling cascades and gene regulatory networks within cells then convert the spatiotemporal morphogen profiles into distinct cellular responses. Current challenges are to understand the diverse molecular and cellular mechanisms underlying morphogen gradient formation, as well as the logic of downstream regulatory circuits involved in morphogen interpretation. This knowledge, combining experimental and theoretical results, is essential to understand emerging properties of morphogen-controlled systems, such as robustness and scaling.

形态发生素对组织发育的控制。
细胞间信号分子,称为形态发生素,在发育中的组织中发挥远距离作用,提供空间信息并控制细胞命运和组织生长等特性。形态素的产生、运输和去除形成了它们在时间和空间上的浓度分布。细胞内的下游信号级联和基因调控网络随后将时空形态发生谱转化为不同的细胞反应。目前的挑战是理解形态形成梯度形成背后的各种分子和细胞机制,以及参与形态形成解释的下游调节回路的逻辑。这些知识结合了实验和理论结果,对于理解形态发生控制系统的新兴特性至关重要,例如鲁棒性和缩放性。
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来源期刊
CiteScore
19.50
自引率
0.00%
发文量
21
期刊介绍: The Annual Review of Cell and Developmental Biology, established in 1985, comprehensively addresses major advancements in cell and developmental biology. Encompassing the structure, function, and organization of cells, as well as the development and evolution of cells in relation to both single and multicellular organisms, the journal explores models and tools of molecular biology. As of the current volume, the journal has transitioned from gated to open access through Annual Reviews' Subscribe to Open program, making all articles published under a CC BY license.
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