Impact of a modified implant macrogeometry on biomechanical parameters and bone-related markers in rats.

IF 2.5 4区医学 Q2 Dentistry

Brazilian Oral Research Pub Date : 2023-01-01 DOI:10.1590/1807-3107bor-2023.vol37.0044

Mounir Colares Mussi, Fernanda Vieira Ribeiro, Monica Grazieli Corrêa, Cristiane Ribeiro Salmon, Suzana Peres Pimentel, Fabiano Ribeiro Cirano, Marcio Zaffalon Casati

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Abstract

This study investigated the impact of a modified implant macrogeometry on peri-implant healing and its effect on bone-related molecules in rats. Eighteen rats received one implant in each tibia: the control group received implants with conventional macrogeometry and the test group received implants with modified macrogeometry. After 30 days, the implants were removed for biomechanical analysis and the bone tissue around them was collected for quantifying gene expression of OPN, Runx2, β-catenin, BMP-2, Dkk1, and RANKL/OPG. Calcein and tetracycline fluorescent markers were used for analyzing newly formed bone at undecalcified sections of the tibial implants. These fluorescent markers showed continuous bone formation at cortical bone width and sparse new bone formed along the medullary implant surface in both groups. However, higher counter-torque values and upregulation of OPN expression were achieved by test implants when compared to controls. The modified macrogeometry of implants optimized peri-implant healing, favoring the modulation of OPN expression in the osseous tissue around the implants.

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改良种植体宏观几何形状对大鼠生物力学参数和骨相关标志物的影响。

本研究探讨了改良种植体宏观结构对大鼠种植体周围愈合的影响及其对骨相关分子的影响。18只大鼠每条胫骨各植入1个假体，对照组采用常规大尺寸假体，试验组采用改良大尺寸假体。30 d后取出植入物进行生物力学分析，收集植入物周围骨组织，定量测定OPN、Runx2、β-catenin、BMP-2、Dkk1、RANKL/OPG基因表达。使用钙黄素和四环素荧光标记分析胫骨种植体未钙化部分新形成的骨。这些荧光标记显示两组在皮质骨宽度处连续骨形成，并且沿髓质种植体表面形成稀疏的新骨。然而，与对照组相比，测试植入物获得了更高的反扭矩值和上调的OPN表达。改良的种植体宏观几何结构优化了种植体周围的愈合，有利于调节种植体周围骨组织中OPN的表达。

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