Utility of Immunohistochemistry in the Diagnosis of Pleuropulmonary and Mediastinal Cancers: A Review and Update.

IF 3.3 3区医学 Q2 MEDICAL LABORATORY TECHNOLOGY

Archives of pathology & laboratory medicine Pub Date : 2024-03-01 DOI:10.5858/arpa.2022-0483-RA

Hongbing Deng

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Abstract

Context.—: Immunohistochemistry has become a valuable ancillary tool for the accurate classification of pleuropulmonary and mediastinal neoplasms necessary for therapeutic decisions and predicting prognostic outcome. Diagnostic accuracy has significantly improved because of the continuous discoveries of tumor-associated biomarkers and the development of effective immunohistochemical panels.

Objective.—: To increase the accuracy of diagnosis and classify pleuropulmonary neoplasms through immunohistochemistry.

Data sources.—: Literature review and the author's research data and personal practice experience.

Conclusions.—: This review article highlights that appropriately selecting immunohistochemical panels enables pathologists to effectively diagnose most primary pleuropulmonary neoplasms and differentiate primary lung tumors from a variety of metastatic tumors to the lung. Knowing the utilities and pitfalls of each tumor-associated biomarker is essential to avoid potential diagnostic errors.

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免疫组化在诊断胸膜肺癌和纵隔癌中的作用：回顾与更新

背景免疫组化已成为胸肺和纵隔肿瘤准确分类的重要辅助工具，是治疗决策和预测预后结果所必需的。由于肿瘤相关生物标记物的不断发现和有效免疫组化板的开发，诊断准确性得到了显著提高：通过免疫组化提高胸膜肺肿瘤诊断和分类的准确性：文献综述以及作者的研究数据和个人实践经验：这篇综述文章强调，适当选择免疫组化试剂盒可使病理学家有效诊断大多数原发性胸肺部肿瘤，并将原发性肺部肿瘤与各种肺部转移性肿瘤区分开来。了解每种肿瘤相关生物标记物的作用和缺陷对于避免潜在的诊断错误至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of pathology & laboratory medicine 医学-病理学

CiteScore

9.20

自引率

2.20%

发文量

369

审稿时长

3-8 weeks

期刊介绍： Welcome to the website of the Archives of Pathology & Laboratory Medicine (APLM). This monthly, peer-reviewed journal of the College of American Pathologists offers global reach and highest measured readership among pathology journals. Published since 1926, ARCHIVES was voted in 2009 the only pathology journal among the top 100 most influential journals of the past 100 years by the BioMedical and Life Sciences Division of the Special Libraries Association. Online access to the full-text and PDF files of APLM articles is free.