Updated Salivary Gland Immunohistochemistry: A Review.

IF 3.7 3区 医学 Q2 MEDICAL LABORATORY TECHNOLOGY
Mohammed Amer Swid, Liping Li, Erin M Drahnak, Hayden Idom, William Quinones
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引用次数: 0

Abstract

Context.—: Salivary gland neoplasms are rare lesions in the head and neck (H&N) pathology realm. There are more than 20 malignant and 15 benign salivary gland neoplasms in the 5th edition of the World Health Organization classification of H&N tumors. These neoplasms consist of heterogeneous groups of uncommon diseases that make diagnosis and treatment challenging for the clinical team. Using an algorithmic immunohistochemical approach-defined tumor origin and type has proven to be effective and advantageous. Immunohistochemistry may be used as sort of a "diagnostic looking glass," not as a positive or negative type tool, but as an indispensable complement to a hematoxylin-eosin morphologic pattern-based approach. Furthermore, the understanding of the novel discoveries of the salivary gland gene fusions and the molecular aspects of these tumors makes the process easier and improve the diagnosis as well as treatment aspects. This review reflects our experience with more recent diagnostic antibodies, which include MYB RNA, Pan-TRK, PLAG1, LEF1, and NR4A3. Each of these is linked with a specific type of neoplasm; for example, gene fusions involving the PLAG1 and HMGA2 oncogenes are specific for benign pleomorphic adenomas, and MYB is associated with adenoid cystic carcinoma.

Objective.—: To review these more recent antibodies, which highly enhance salivary gland neoplasm diagnosis.

Data sources.—: The study sources involved literature PubMed searches, including multiple review articles, case reports, selected book chapters, and Geisinger Medical Center cases.

Conclusions.—: Salivary gland tumors are a rare, varied group of lesions in H&N pathology. We need to have continuous readings and revisions of the molecular consequences of these fusion oncoproteins and their subsequent targets, which will eventually lead to the identification of novel driver genes in salivary gland neoplasms.

最新涎腺免疫组织化学:综述。
上下文。-:唾液腺肿瘤是头颈部(H&N)病理领域罕见的病变。在世界卫生组织第5版的H&N肿瘤分类中,恶性唾液腺肿瘤有20多种,良性唾液腺肿瘤有15种。这些肿瘤由不同种类的罕见疾病组成,使得临床团队的诊断和治疗具有挑战性。使用算法免疫组织化学方法确定肿瘤起源和类型已被证明是有效和有利的。免疫组织化学可以作为一种“诊断镜”,不是作为阳性或阴性类型的工具,而是作为苏木精-伊红形态学模式为基础的方法不可或缺的补充。此外,对唾液腺基因融合和这些肿瘤分子方面的新发现的理解使这一过程更容易,并改善了诊断和治疗方面。这篇综述反映了我们在最近的诊断抗体方面的经验,包括MYB RNA、Pan-TRK、PLAG1、LEF1和NR4A3。每一种都与一种特定类型的肿瘤有关;例如,涉及PLAG1和HMGA2癌基因的基因融合是良性多形性腺瘤的特异性基因,而MYB与腺样囊性癌相关。-:回顾这些最近的抗体,高度提高唾液腺肿瘤的诊断。数据源。-:研究来源涉及文献PubMed检索,包括多篇综述文章、病例报告、精选书籍章节和Geisinger医学中心病例。唾液腺肿瘤是H&N病理中一种罕见的、多样的病变。我们需要不断阅读和修订这些融合癌蛋白及其后续靶标的分子后果,这将最终导致唾液腺肿瘤中新的驱动基因的鉴定。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
9.20
自引率
2.20%
发文量
369
审稿时长
3-8 weeks
期刊介绍: Welcome to the website of the Archives of Pathology & Laboratory Medicine (APLM). This monthly, peer-reviewed journal of the College of American Pathologists offers global reach and highest measured readership among pathology journals. Published since 1926, ARCHIVES was voted in 2009 the only pathology journal among the top 100 most influential journals of the past 100 years by the BioMedical and Life Sciences Division of the Special Libraries Association. Online access to the full-text and PDF files of APLM articles is free.
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