Physical Exercise and Serum BDNF Levels: Accounting for the Val66Met Polymorphism in Older Adults.

IF 1.3 4区医学 Q4 BEHAVIORAL SCIENCES

Cognitive and Behavioral Neurology Pub Date : 2023-12-01 DOI:10.1097/WNN.0000000000000349

Oda Bugge Kambestad, Kristine Sirevåg, Jelena Mrdalj, Anders Hovland, Trygve Bruun Endal, Eva Andersson, Trond Sjøbø, Silje Haukenes Stavestrand

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引用次数: 0

Abstract

Background: Brain-derived neurotrophic factor (BDNF) expression, which can be measured in blood serum, has been found to increase with aerobic exercise. The link between BDNF level, physical exercise, and genetic status (Val66Met polymorphism) has not been well researched in older adults.

Objective: To investigate the possible link between BDNF expression, acute aerobic exercise, and the Val66Met polymorphism in older adults.

Method: Twenty-three healthy older adults participated in one session of acute aerobic exercise. Their serum BDNF levels were measured both at baseline and post exercise. Saliva samples were collected to identify each individual's genetic status.

Results: At baseline, the individuals' mean serum BDNF level was 16.03 ng/mL (Val66Val = 15.89 ng/mL; Val66Met = 16.34 ng/mL); post exercise, the individuals' mean serum BDNF level was 16.81 ng/mL (Val66Val = 16.14 ng/mL; Val66Met = 18.34 ng/mL).

Conclusion: One session of acute aerobic exercise significantly increased the individuals' mean serum BDNF level. Males had higher BDNF levels than females. There was a significant interaction between gender and BDNF expression post exercise and a significant between-group effect of gender. The Val66Met carriers had a more positive response to the acute aerobic exercise compared with the Val66Val carriers, although without a significant difference between the two groups.

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体育锻炼和血清BDNF水平:老年人Val66Met多态性的解释

研究背景:脑源性神经营养因子(BDNF)在血清中的表达随着有氧运动的增加而增加。BDNF水平、体育锻炼和遗传状态(Val66Met多态性)之间的联系尚未在老年人中得到很好的研究。目的:探讨老年人BDNF表达、急性有氧运动和Val66Met多态性之间的可能联系。方法:23名健康老年人参加一组急性有氧运动。在基线和运动后测量他们的血清BDNF水平。收集唾液样本以确定每个人的遗传状况。结果:基线时，个体平均血清BDNF水平为16.03 ng/mL (Val66Val = 15.89 ng/mL;Val66Met = 16.34 ng/mL);运动后，个体平均血清BDNF水平为16.81 ng/mL (Val66Val = 16.14 ng/mL;Val66Met = 18.34 ng/mL)。结论:一次急性有氧运动可显著提高个体血清BDNF水平。男性的BDNF水平高于女性。运动后BDNF表达与性别有显著交互作用，性别组间效应显著。与Val66Val携带者相比，Val66Met携带者对急性有氧运动有更积极的反应，尽管两组之间没有显著差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cognitive and Behavioral Neurology 医学-行为科学

CiteScore

2.40

自引率

7.10%

发文量

审稿时长

>12 weeks

期刊介绍： Cognitive and Behavioral Neurology (CBN) is a forum for advances in the neurologic understanding and possible treatment of human disorders that affect thinking, learning, memory, communication, and behavior. As an incubator for innovations in these fields, CBN helps transform theory into practice. The journal serves clinical research, patient care, education, and professional advancement. The journal welcomes contributions from neurology, cognitive neuroscience, neuropsychology, neuropsychiatry, and other relevant fields. The editors particularly encourage review articles (including reviews of clinical practice), experimental and observational case reports, instructional articles for interested students and professionals in other fields, and innovative articles that do not fit neatly into any category. Also welcome are therapeutic trials and other experimental and observational studies, brief reports, first-person accounts of neurologic experiences, position papers, hypotheses, opinion papers, commentaries, historical perspectives, and book reviews.