Exploring scavenger receptor class F member 2 and the importance of scavenger receptor family in prediagnostic diseases.

IF 1.6 4区医学 Q4 TOXICOLOGY

Toxicological Research Pub Date : 2023-04-14 eCollection Date: 2023-07-01 DOI:10.1007/s43188-023-00176-2

Thuy-Trang T Vo, Gyeyeong Kong, Chaeyeong Kim, Uijin Juang, Suhwan Gwon, Woohyeong Jung, Huonggiang Nguyen, Seon-Hwan Kim, Jongsun Park

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Abstract

Scavenger Receptor Class F Member 2 (SCARF2), also known as the Type F Scavenger Receptor Family gene, encodes for Scavenger Receptor Expressed by Endothelial Cells 2 (SREC-II). This protein is a crucial component of the scavenger receptor family and is vital in protecting mammals from infectious diseases. Although research on SCARF2 is limited, mutations in this protein have been shown to cause skeletal abnormalities in both SCARF2-deficient mice and individuals with Van den Ende-Gupta syndrome (VDEGS), which is also associated with SCARF2 mutations. In contrast, other scavenger receptors have demonstrated versatile responses and have been found to aid in pathogen elimination, lipid transportation, intracellular cargo transportation, and work in tandem with various coreceptors. This review will concentrate on recent progress in comprehending SCARF2 and the functions played by members of the Scavenger Receptor Family in pre-diagnostic diseases.

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探索清道夫受体F类成员2和清道夫受体家族在诊断前疾病中的重要性。

清道夫受体F类成员2（SCARF2），也称为F型清道夫受体家族基因，编码内皮细胞表达的清道夫受体2（SREC-II）。这种蛋白质是清道夫受体家族的重要组成部分，对保护哺乳动物免受传染病的侵袭至关重要。尽管对SCARF2的研究有限，但该蛋白的突变已被证明会导致SCARF2缺陷小鼠和Van den Ende-Gupta综合征（VDEGS）患者的骨骼异常，这也与SCARF2突变有关。相反，其他清除剂受体已显示出多功能反应，并被发现有助于病原体消除、脂质运输、细胞内货物运输，并与各种辅助受体协同工作。这篇综述将集中于理解SCARF2的最新进展以及清除剂受体家族成员在预诊断疾病中发挥的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Toxicological Research TOXICOLOGY-

CiteScore

4.20

自引率

4.30%

发文量

期刊介绍： Toxicological Research is the official journal of the Korean Society of Toxicology. The journal covers all areas of Toxicological Research of chemicals, drugs and environmental agents affecting human and animals, which in turn impact public health. The journal’s mission is to disseminate scientific and technical information on diverse areas of toxicological research. Contributions by toxicologists, molecular biologists, geneticists, biochemists, pharmacologists, clinical researchers and epidemiologists with a global view on public health through toxicological research are welcome. Emphasis will be given to articles providing an understanding of the toxicological mechanisms affecting animal, human and public health. In the case of research articles using natural extracts, detailed information with respect to the origin, extraction method, chemical profiles, and characterization of standard compounds to ensure the reproducible pharmacological activity should be provided.