Change in Maladaptive Behavior Affects Intergenerational Relationships in Fragile X Syndrome.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2022-05-01 DOI:10.1352/1944-7558-127.3.231

Emily Lorang, Jinkuk Hong, Leann Smith DaWalt, Marsha Mailick

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引用次数: 0

Abstract

This study investigated the bidirectional effects of change in maladaptive behaviors among adolescents and adults with fragile X syndrome (FXS) and change in their intergenerational family relationships over a 7.5-year period. Indicators of the intergenerational family relationship between premutation carrier mothers and their adolescent or adult son/daughter with FXS included a measure of the quality of the relationship, as well as descriptions provided by mothers of their relationship with their son/daughter (positive remarks, critical remarks). Maladaptive behaviors decreased, maternal positive remarks increased, and maternal critical remarks and relationship quality remained stable over time. Bidirectional effects of change were observed in predicting maladaptive behaviors and maternal positive remarks, although maladaptive behaviors more strongly predicted positive remarks than the reciprocal association. This research suggests prioritizing maladaptive behaviors in the context of family interventions.

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适应不良行为的改变影响脆性X综合征的代际关系。

本研究在7.5年的时间里，探讨了青少年和成人脆性X综合征(FXS)患者适应不良行为的变化及其代际家庭关系的变化的双向影响。先兆携带者母亲与其患有FXS的青春期或成年儿子/女儿之间的代际家庭关系的指标包括对关系质量的衡量，以及母亲对其与儿子/女儿关系的描述(积极评论，批评评论)。随着时间的推移，适应不良行为减少，母亲的积极言论增加，母亲的批评言论和关系质量保持稳定。变化在预测适应不良行为和母亲正面评价方面存在双向效应，但适应不良行为对正面评价的预测作用强于相互作用。这项研究建议在家庭干预的背景下优先考虑适应不良行为。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.