Microbiota and fungal-bacterial interactions in the cystic fibrosis lung.

IF 10.1 2区 生物学 Q1 MICROBIOLOGY
Eneko Santos-Fernandez, Leire Martin-Souto, Aitziber Antoran, Maialen Areitio, Leire Aparicio-Fernandez, Jean-Philippe Bouchara, Carsten Schwarz, Aitor Rementeria, Idoia Buldain, Andoni Ramirez-Garcia
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引用次数: 0

Abstract

The most common genetic hereditary disease affecting Caucasians is cystic fibrosis (CF), which is caused by autosomal recessive mutations in the CFTR gene. The most serious consequence is the production of a thick and sticky mucus in the respiratory tract, which entraps airborne microorganisms and facilitates colonization, inflammation and infection. Therefore, the present article compiles the information about the microbiota and, particularly, the inter-kingdom fungal-bacterial interactions in the CF lung, the molecules involved and the potential effects that these interactions may have on the course of the disease. Among the bacterial compounds, quorum sensing-regulated molecules such as homoserine lactones, phenazines, rhamnolipids, quinolones and siderophores (pyoverdine and pyochelin) stand out, but volatile organic compounds, maltophilin and CF-related bacteriophages are also explained. These molecules exhibit diverse antifungal mechanisms, including iron starvation and induction of reactive oxygen and nitrogen species production. The fungal compounds are less studied, but they include cell wall components, siderophores, patulin and farnesol. Despite the apparent competition between microorganisms, the persistence of significant rates of bacterial-fungal co-colonization in CF suggests that numerous variables influence it. In conclusion, it is crucial to increase scientific and economic efforts to intensify studies on the bacterial-fungal inter-kingdom interactions in the CF lung.

囊性纤维化肺的微生物群和真菌-细菌相互作用。
影响白种人的最常见的遗传性疾病是囊性纤维化(CF),这是由CFTR基因的常染色体隐性突变引起的。最严重的后果是在呼吸道中产生粘稠的粘液,使空气中的微生物滞留,促进定植、炎症和感染。因此,本文汇编了有关CF肺中微生物群的信息,特别是真菌-细菌间的相互作用,所涉及的分子以及这些相互作用可能对疾病进程产生的潜在影响。在细菌化合物中,群体感应调节的分子如同丝氨酸内酯、非那嗪、鼠李糖脂、喹诺酮类和铁细胞(pyoverdine和pyochelin)很突出,但挥发性有机化合物、麦芽酚素和与csf相关的噬菌体也得到了解释。这些分子表现出多种抗真菌机制,包括铁饥饿和诱导活性氧和氮的产生。真菌化合物的研究较少,但它们包括细胞壁成分,铁载体,棒霉素和法尼醇。尽管微生物之间存在明显的竞争,但CF中细菌-真菌共定殖的持续显著率表明,有许多变量影响它。总之,加强对CF肺中细菌-真菌相互作用的科学和经济研究是至关重要的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
FEMS microbiology reviews
FEMS microbiology reviews 生物-微生物学
CiteScore
17.50
自引率
0.90%
发文量
45
审稿时长
6-12 weeks
期刊介绍: Title: FEMS Microbiology Reviews Journal Focus: Publishes reviews covering all aspects of microbiology not recently surveyed Reviews topics of current interest Provides comprehensive, critical, and authoritative coverage Offers new perspectives and critical, detailed discussions of significant trends May contain speculative and selective elements Aimed at both specialists and general readers Reviews should be framed within the context of general microbiology and biology Submission Criteria: Manuscripts should not be unevaluated compilations of literature Lectures delivered at symposia must review the related field to be acceptable
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