Waning of Antibody Response Among Vaccinees who Received Two Doses of Covishield Vaccine.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-01-01 DOI:10.4103/jgid.jgid_128_22

Shivani Haritay, Rithia Patil, Arif Maldar, Anil Kumar, Vikrama Reddy, Deshna Oswal, Masood Ahmed Tahashildar, Akshay Kolakar, Satish Kabbur, Jang Bahadur Prasad, M S Shivaswamy, Ramesh Paranjape, Mubashir Angolkar

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Abstract

Introduction: There are limited data available on the long-term presence of SARS-CoV-2-specific binding antibodies and neutralizing antibodies in circulation among the elderly population. This study aims to examine levels of anti-SARS-CoV-2 antibodies in vaccines who have completed at least 6 months since the second vaccine dose. A cross-sectional study was conducted from November 2021 to January 2022 among 199 vaccines aged 60 years and above residing in Belagavi city, who received two doses of the Covishield vaccine.

Methods: Antibody response to SARS-COV-2 virus whole cell antigen was measured by a kit COVID KAWACH IgG Micro LISA (J Mitra and Company, India) in 199 participants who had completed at least 6 months after receiving the second dose of Covishield vaccine. The antibody response was measured as a ratio of optical density (OD) in the participant's sample to the mean OD in negative control test by normal (T/N). Independent Kruskal-Wallis test was applied to test the difference between the T/N ratio by months of vaccination since the second dose and by the age group strata.

Results: The median T/N values among participants who completed 6, 7, 8, and 9 months since the second vaccine dose were 14.17, 10.46, 7.93, and 5.11, respectively, and this decline in T/N values was statistically significant. Antibody response values showed a decline with increasing age for participants in the age strata 60-69, 70-79, and 80 and above, respectively.

Conclusions: A significant decline was observed in antibody response over 9 months supporting the administration of booster dose of vaccine.

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接种两剂Covishield疫苗的人抗体反应减弱。

关于老年人血液循环中长期存在sars - cov -2特异性结合抗体和中和抗体的数据有限。本研究旨在检测自第二剂疫苗接种后至少6个月的疫苗中抗sars - cov -2抗体的水平。从2021年11月至2022年1月，对居住在贝拉加维市的199名60岁及以上的疫苗接种者进行了一项横断面研究，他们接种了两剂Covishield疫苗。方法:采用COVID KAWACH IgG Micro LISA试剂盒(J Mitra and Company, India)检测199例接种第二剂Covishield疫苗后至少6个月的受试者对SARS-COV-2病毒全细胞抗原的抗体反应。抗体反应以参与者样本的光密度(OD)与阴性对照试验中平均OD的比值(T/N)来衡量。采用独立的Kruskal-Wallis试验来检测自第二次接种以来接种的月份和年龄组层之间的T/N比率的差异。结果:接种第二次疫苗后6、7、8和9个月的参与者中位T/N值分别为14.17、10.46、7.93和5.11,T/N值的下降具有统计学意义。抗体应答值在60-69岁、70-79岁和80岁及以上年龄段分别随着年龄的增加而下降。结论:9个月后，支持接种加强剂疫苗的抗体应答显著下降。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.