Bifunctional reagents in organic synthesis

IF 51.7 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nature reviews. Chemistry Pub Date : 2021-04-12 DOI:10.1038/s41570-021-00266-5

Huan-Ming Huang, Peter Bellotti, Jiajia Ma, Toryn Dalton, Frank Glorius

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引用次数: 43

Abstract

Developments in synthetic chemistry are increasingly driven by improvements in the selectivity and sustainability of transformations. Bifunctional reagents, either as dual coupling partners or as a coupling partner in combination with an activating species, offer an atom-economic approach to chemical complexity, while suppressing the formation of waste. These reagents are employed in organic synthesis thanks to their ability to form complex organic architectures and empower novel reaction pathways. This Review describes several key bifunctional reagents by showcasing selected cornerstone research areas and examples, including radical reactions, C–H functionalization, cross-coupling, organocatalysis and cyclization reactions. Developments in synthetic chemistry are increasingly driven by attempts to improve both selectivity and sustainability. This Review highlights the versatility of bifunctional reagents in generating chemical complexity with enhanced atom-economy-leveraging radical reactions, C–H functionalizations, cross-couplings, organocatalysed processes and cyclizations.

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有机合成中的双功能试剂

合成化学的发展日益受到转化选择性和可持续性改进的推动。双功能试剂，无论是作为双重偶联剂，还是作为偶联剂与活化物质的组合，都为化学复杂性提供了一种原子经济的方法，同时抑制了废物的形成。这些试剂能够形成复杂的有机结构并赋予新的反应途径，因此被广泛应用于有机合成。本综述通过展示选定的基础研究领域和实例，介绍了几种关键的双功能试剂，包括自由基反应、C-H 功能化、交叉偶联、有机催化和环化反应。合成化学的发展日益受到提高选择性和可持续性的推动。本综述重点介绍了双功能试剂在利用自由基反应、C-H 功能化、交叉耦合、有机催化过程和环化反应提高原子经济性以产生化学复杂性方面的多功能性。

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来源期刊

Nature reviews. Chemistry Chemical Engineering-General Chemical Engineering

CiteScore

52.80

自引率

0.80%

发文量

期刊介绍： Nature Reviews Chemistry is an online-only journal that publishes Reviews, Perspectives, and Comments on various disciplines within chemistry. The Reviews aim to offer balanced and objective analyses of selected topics, providing clear descriptions of relevant scientific literature. The content is designed to be accessible to recent graduates in any chemistry-related discipline while also offering insights for principal investigators and industry-based research scientists. Additionally, Reviews should provide the authors' perspectives on future directions and opinions regarding the major challenges faced by researchers in the field.