Health risk assessment of exposure to triclosan in pregnant women using Monte Carlo simulation techniques: based on biomonitoring data.

IF 1.2 4区环境科学与生态学 Q4 ENVIRONMENTAL SCIENCES

Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis Pub Date : 2023-01-01 Epub Date: 2023-06-27 DOI:10.1080/26896583.2023.2226587

Elham Attarian, Farzaneh Mohammadi, Karim Ebrahimpour, Malihe Moazeni, Mohammadreza Maracy, Afshin Ebrahimi, Roya Kelishadi

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Abstract

This study aimed to assess the triclosan (TCS) health risk in an Iranian pregnant women sample by Monte Carlo simulation (MCS). The urinary TCS of 99 women after the 28^th week of pregnancy was detected by gas chromatography/mass spectrometry detector (GC/MS), and the MCS model implemented a health risk assessment. The corresponding hazard quotient (HQ) and the sensitivity analysis were calculated. TCS was measured in 100% of the urine samples with a median concentration of 2.89 µg/L. The median of HQ was obtained at 1.93 × 10^-4. The TCS exposure risk in the studied population was lower than the allowable limit. A comparison between HQ values in the two weight subgroups of pregnant women showed that the risk level is almost equal, and there was minimal health risk in pregnant women from exposure to TCS.

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利用蒙特卡洛模拟技术对孕妇接触三氯生的健康风险进行评估：基于生物监测数据。

本研究旨在通过蒙特卡罗模拟（MCS）评估伊朗孕妇样本中三氯生（TCS）的健康风险。通过气相色谱/质谱检测器（GC/MS）检测了 99 名怀孕 28 周后的孕妇尿液中的三氯生（TCS），并利用 MCS 模型进行了健康风险评估。计算了相应的危害商数（HQ）和敏感性分析。100%的尿样中都检测到了三氯氢硅，浓度中位数为 2.89 微克/升。HQ 的中位数为 1.93 × 10-4。研究人群接触三氯氢硅的风险低于允许限值。对孕妇两个体重分组的 HQ 值进行比较后发现，风险水平几乎相等，孕妇接触三氯苯酚对健康造成的风险极小。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis Multiple-

CiteScore

4.60

自引率

0.00%

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