Dietary exposure to thyroid disrupting chemicals: a community-based study in Canada.

IF 1.2 4区 环境科学与生态学 Q4 ENVIRONMENTAL SCIENCES
Nicole Babichuk, Atanu Sarkar, Shree Mulay, John Knight, Edward Randell
{"title":"Dietary exposure to thyroid disrupting chemicals: a community-based study in Canada.","authors":"Nicole Babichuk, Atanu Sarkar, Shree Mulay, John Knight, Edward Randell","doi":"10.1080/26896583.2023.2174763","DOIUrl":null,"url":null,"abstract":"<p><p>The marine ecosystem around the Island of Newfoundland is contaminated by thyroid disrupting chemicals (TDCs). Coastal inhabitants may be exposed to TDCs through consumption of contaminated local seafood products and affecting thyroid functions. The aim of this study was to explore: (1) consumption frequency of local seafood products consumed by rural residents, (2) thyroid hormones (THs) and TDCs concentrations in residents, (3) relationships between local seafood consumption, TDC concentrations, and THs. Participants (<i>n</i> = 80) were recruited from two rural Newfoundland communities. Seafood consumption was measured through a validated seafood consumption questionnaire. Blood samples were collected from all participants and tested for THs (thyroid stimulating hormone, free thyroxine, free triiodothyronine) and TDCs, including polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs), polybrominated biphenyls (PBBs), and dichlorodiphenyldichloroethylene (p,p'-DDE). Cod was the most frequently consumed local species, but there was a wide range of other local species consumed. Older participants (>50 years) had greater plasma concentrations of PBB-153, PCBs and p,p'-DDE, and males had higher concentrations of all TDCs than females. The consumption frequency of local cod was found to be positively associated with several PCB congeners, p,p'-DDE and ∑<sub>14</sub>TDCs. There was no significant relationship between TDCs and THs in either simple or multivariate linear regression analyses.</p>","PeriodicalId":53200,"journal":{"name":"Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis","volume":"41 1-2","pages":"1-21"},"PeriodicalIF":1.2000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis","FirstCategoryId":"93","ListUrlMain":"https://doi.org/10.1080/26896583.2023.2174763","RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/3/6 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"ENVIRONMENTAL SCIENCES","Score":null,"Total":0}
引用次数: 1

Abstract

The marine ecosystem around the Island of Newfoundland is contaminated by thyroid disrupting chemicals (TDCs). Coastal inhabitants may be exposed to TDCs through consumption of contaminated local seafood products and affecting thyroid functions. The aim of this study was to explore: (1) consumption frequency of local seafood products consumed by rural residents, (2) thyroid hormones (THs) and TDCs concentrations in residents, (3) relationships between local seafood consumption, TDC concentrations, and THs. Participants (n = 80) were recruited from two rural Newfoundland communities. Seafood consumption was measured through a validated seafood consumption questionnaire. Blood samples were collected from all participants and tested for THs (thyroid stimulating hormone, free thyroxine, free triiodothyronine) and TDCs, including polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs), polybrominated biphenyls (PBBs), and dichlorodiphenyldichloroethylene (p,p'-DDE). Cod was the most frequently consumed local species, but there was a wide range of other local species consumed. Older participants (>50 years) had greater plasma concentrations of PBB-153, PCBs and p,p'-DDE, and males had higher concentrations of all TDCs than females. The consumption frequency of local cod was found to be positively associated with several PCB congeners, p,p'-DDE and ∑14TDCs. There was no significant relationship between TDCs and THs in either simple or multivariate linear regression analyses.

甲状腺干扰化学物质的膳食暴露:一项基于加拿大社区的研究。
纽芬兰岛周围的海洋生态系统受到甲状腺干扰化学物(TDCs)的污染。沿海居民可能会通过食用受污染的本地海鲜产品而接触到 TDCs,从而影响甲状腺功能。本研究旨在探讨:(1)农村居民食用当地海鲜产品的频率;(2)居民体内的甲状腺激素(THs)和TDCs浓度;(3)当地海鲜食用量、TDC浓度和THs之间的关系。参与者(n = 80)来自纽芬兰省的两个农村社区。海鲜消费通过有效的海鲜消费问卷进行测量。采集了所有参与者的血液样本,并对 THs(促甲状腺激素、游离甲状腺素、游离三碘甲状腺原氨酸)和 TDCs(包括多溴联苯醚 (PBDEs)、多氯联苯 (PCBs)、多溴联苯 (PBBs) 和二氯二苯二氯乙烯 (p,p'-DDE) )进行了检测。鳕鱼是最常食用的本地鱼种,但也食用多种其他本地鱼种。年龄较大的参与者(50 岁以上)血浆中 PBB-153、多氯联苯和 p,p'-DDE 的浓度较高,男性血浆中所有 TDC 的浓度均高于女性。研究发现,本地鳕鱼的食用频率与几种多氯联苯同系物、p,p'-DDE 和 ∑14TDCs 呈正相关。在简单或多元线性回归分析中,TDCs 与 THs 之间均无明显关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
4.60
自引率
0.00%
发文量
10
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信