Analysis of systemic inflammatory and coagulation biomarkers in advanced cervical cancer: Prognostic and predictive significance.

IF 2.3 4区 医学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Ningfeng Li, Yan Zhang, Wenjie Qu, Chao Zhang, Zhaoxia Ding, Linlin Wang, Baoxia Cui
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引用次数: 2

Abstract

Objective: Peripheral systemic inflammatory, nutritional, and coagulation biomarkers have prognostic and predictive value in various malignancies. We evaluated the prognostic and predictive roles of systemic inflammatory, nutritional, and coagulation biomarkers in the circulating blood of patients with advanced cervical cancer.

Methods: A retrospective study of 795 patients with cervical cancer who received concurrent chemoradiation therapy was performed. Overall survival was evaluated by the Kaplan-Meier estimator. Univariate and multivariate Cox regression models were used to determine prognostic factors associated with overall survival.

Results: The median follow-up time was 76 months. In the univariate analysis, overall survival showed positive prognostic value in patients with a platelet-to-lymphocyte ratio (PLR) <164.29 (P = 0.010), and a plasma fibrinogen (FIB) level <4 g/L(P = 0.012). In the multivariate analysis, the PLR (P = 0.036), and FIB level (P = 0.047) maintained their significance for overall survival. Therefore, the PLR and FIB levels are independent prognostic factors in patients with advanced cervical cancer.

Conclusions: Systemic inflammatory and coagulation biomarkers could help to understand survival differences in the clinical treatment of advanced cervical cancer. The PLR and FIB levels are independent prognostic factors of poor survival in patients with advanced cervical cancer.

晚期宫颈癌的全身炎症和凝血生物标志物分析:预后和预测意义。
目的:外周血系统炎症、营养和凝血生物标志物在各种恶性肿瘤中具有预后和预测价值。我们评估了晚期宫颈癌患者循环血液中系统性炎症、营养和凝血生物标志物的预后和预测作用。方法:对795例同步放化疗的宫颈癌患者进行回顾性研究。用Kaplan-Meier估计器评估总生存率。使用单因素和多因素Cox回归模型来确定与总生存相关的预后因素。结果:中位随访时间76个月。在单因素分析中,血小板与淋巴细胞比值(PLR) P = 0.010和血浆纤维蛋白原(FIB)水平P = 0.012的患者的总生存率显示出积极的预后价值。在多因素分析中,PLR (P = 0.036)和FIB水平(P = 0.047)对总生存率保持显著性。因此,PLR和FIB水平是影响晚期宫颈癌患者预后的独立因素。结论:全身炎症和凝血生物标志物有助于了解晚期宫颈癌临床治疗中的生存差异。PLR和FIB水平是晚期宫颈癌患者生存不良的独立预后因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
International Journal of Biological Markers
International Journal of Biological Markers 医学-生物工程与应用微生物
CiteScore
4.10
自引率
0.00%
发文量
43
期刊介绍: IJBM is an international, online only, peer-reviewed Journal, which publishes original research and critical reviews primarily focused on cancer biomarkers. IJBM targets advanced topics regarding the application of biomarkers in oncology and is dedicated to solid tumors in adult subjects. The clinical scenarios of interests are screening and early diagnosis of cancer, prognostic assessment, prediction of the response to and monitoring of treatment.
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