Sufentanil for carboprost-induced adverse reactions during cesarean delivery under combined spinal-epidural anesthesia.

IF 1.2 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Ginekologia polska Pub Date : 2023-01-01 DOI:10.5603/GP.a2021.0262

Qian Hu, Jin Guo, Peng Bai, Xue Xiao, Teng He, Peng Yang, Huafeng Li, Lin Zhang

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引用次数: 1

Abstract

Objectives: Carboprost plays an important role in managing refractory uterine atony and severe postpartum hemorrhage. However, it is associated with challenging adverse reactions. We aimed to evaluate the clinical effects of low dose sufentanil on the prevention of adverse events associated with carboprost during cesarean delivery.

Material and methods: Patients were randomly divided into two groups: a placebo control group (group C, n = 15) that received an intravenous infusion of 1 mL of normal saline 2 min before carboprost and a sufentanil group (group S, n = 15) that received 5 μg of sufentanil. The primary outcome was the incidence of nausea and vomiting following carboprost administration.

Results: The incidence of nausea, vomiting, and gastrointestinal discomfort was significantly lower in group S than in group C (p < 0.05).

Conclusions: The prophylactic use of low dose sufentanil reduces the incidence of gastrointestinal side effects caused by carboprost administration during cesarean section.

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舒芬太尼治疗腰硬联合麻醉下剖宫产时卡前列素引起的不良反应。

目的:卡前列素在治疗难治性子宫张力和重度产后出血中发挥重要作用。然而，它与具有挑战性的不良反应有关。我们的目的是评估低剂量舒芬太尼预防剖宫产中与卡前列素相关的不良事件的临床效果。材料与方法:将患者随机分为两组:安慰剂对照组(C组，n = 15)，在卡前列素治疗前2 min静脉滴注生理盐水1 mL;舒芬太尼组(S组，n = 15)，舒芬太尼5 μg。主要结局是卡前列素给药后恶心和呕吐的发生率。结果:S组恶心、呕吐、胃肠道不适发生率明显低于C组(p < 0.05)。结论:剖宫产术中预防性使用小剂量舒芬太尼可减少卡前列素引起的胃肠道不良反应的发生。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ginekologia polska OBSTETRICS & GYNECOLOGY-

CiteScore

2.00

自引率

15.40%

发文量

317

审稿时长

4-8 weeks

期刊介绍： Ginekologia Polska’ is a monthly medical journal published in Polish and English language. ‘Ginekologia Polska’ will accept submissions relating to any aspect of gynaecology, obstetrics and areas directly related. ‘Ginekologia Polska’ publishes original contributions, comparative works, case studies, letters to the editor and many other categories of articles.