The East Asian gut microbiome and its role in oncology: a narrative review.

IF 1.9 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Singapore medical journal Pub Date : 2025-08-01 Epub Date: 2023-06-01 DOI:10.4103/singaporemedj.SMJ-2022-042

Evelyn Yi Ting Wong, Jonathan Wei Jie Lee, Jeremy Fung Yen Lim, Han Chong Toh

引用次数: 0

Abstract

Abstract: The field of onco-microbiome is rapidly expanding. Multiple studies have shown the crucial role of gut microbiota in the regulation of nutrient metabolism, immunomodulation and protection against pathogens. Tools for manipulating the gut microbiota include dietary modification and faecal microbiota transfer. Accumulating evidence has also documented the application of specific intestinal microbiome in cancer immunotherapy, notably in enhancing the efficacy of immune checkpoint inhibitors. The aim of this review is to focus on the East Asian microbiome and to provide a current overview of microbiome science and its clinical application in cancer biology and immunotherapy.

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东亚肠道微生物组及其在肿瘤学中的作用：综述。

摘要：肿瘤微生物组研究领域正在迅速发展。多项研究表明，肠道菌群在调节营养代谢、免疫调节和抵御病原体方面发挥着至关重要的作用。控制肠道微生物群的工具包括饮食调整和粪便微生物群转移。越来越多的证据也证明了特定肠道微生物组在癌症免疫治疗中的应用，特别是在增强免疫检查点抑制剂的疗效方面。本文就东亚微生物组的研究现状及其在肿瘤生物学和免疫治疗中的临床应用进行综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Singapore medical journal MEDICINE, GENERAL & INTERNAL-

CiteScore

3.40

自引率

3.70%

发文量

149

审稿时长

3-6 weeks

期刊介绍： The Singapore Medical Journal (SMJ) is the monthly publication of Singapore Medical Association (SMA). The Journal aims to advance medical practice and clinical research by publishing high-quality articles that add to the clinical knowledge of physicians in Singapore and worldwide. SMJ is a general medical journal that focuses on all aspects of human health. The Journal publishes commissioned reviews, commentaries and editorials, original research, a small number of outstanding case reports, continuing medical education articles (ECG Series, Clinics in Diagnostic Imaging, Pictorial Essays, Practice Integration & Life-long Learning [PILL] Series), and short communications in the form of letters to the editor.