Clinico-epidemiological profile and outcome of infected health care workers during the three consecutive waves of COVID-19 pandemic: a longitudinal cohort study.

Q2 Medicine
Merrin Mathew, Juny Sebastian, Narayanappa Doddaiah, Anmaria Thomas, Sinchana Narayanappa
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引用次数: 1

Abstract

Background: Health care workers are considered as high-risk population, who deal with many unknown, undiagnosed, and subclinical infectious diseases in their daily life. Currently, the COVID-19 pandemic posed as an add-on burden for these frontline workers in all aspects. Although, many adverse physical and mental effects of pandemic among health care workers (HCWs) were discussed worldwide, a long-term study for delayed complications needed to be explored.

Aim: The study evaluates and compares three waves of the pandemic in various aspects such as the incidence, prevalence, severity, risk factors, and variations in the pattern of COVID-19 infection, impact of vaccination, and post-infection complications among the HCWs.

Methodology: A longitudinal observational study was carried out over a period of 2 years and another 6 months for follow-up. The study included all HCWs who tested positive in any one wave of COVID-19 pandemic with any one of the confirmed COVID-19 test. Each COVID-19-affected HCW was followed up through telephone calls and direct interviews conducted at the study site. Admission details and other background details of the study population were collected from the hospital records.

Results: A total of 968 HCWs were COVID-19 positive in any of the three waves, and highest incidence (53.00%) was caused by the Omicron variant. High severity and hospitalization was observed in the first wave (no vaccination) and fully immunized personnel were found to be out of danger of being hospitalized during all succeeding waves (chi-square value: 87.04, p < 0.05). Predictors such as female gender, occupational exposure, and comorbid status were identified as possible risk factors for infection. A total of 70 HCWs reported with 104 complications, of which chronic diseases such as new onset of diabetes (n = 3), cardiovascular events (n = 8), worsening of preexisting comorbidities (n = 8), etc. were found out.

Conclusions: This study proves the benefit of being immunized rather than the risk of being infected. This study documents that immunization impacted complication and hospitalization rates of COVID-19 infection. This evidence may help in tackling vaccine hesitancy across the nations.

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连续三波COVID-19大流行期间受感染医护人员的临床流行病学概况和结局:一项纵向队列研究
背景:卫生保健工作者被认为是高危人群,他们在日常生活中要处理许多未知的、未诊断的、亚临床的传染病。当前,新冠肺炎疫情给一线工作者带来了方方面面的额外负担。虽然世界范围内讨论了大流行对卫生保健工作者(HCWs)的许多不利身心影响,但需要对迟发性并发症进行长期研究。目的:对三波新冠肺炎大流行的发生率、流行率、严重程度、危险因素、感染模式变化、疫苗接种影响、感染后并发症等方面进行评价和比较。方法:进行了为期2年的纵向观察研究和6个月的随访。该研究包括在任何一波COVID-19大流行中检测呈阳性的所有医护人员,其中包括任何一项确诊的COVID-19检测。通过电话和在研究现场进行的直接访谈,对每位受covid -19影响的HCW进行了随访。从医院记录中收集了研究人群的入院细节和其他背景细节。结果:三波共968例HCWs COVID-19阳性,其中Omicron变异发生率最高(53.00%)。在第一波(未接种疫苗)中观察到严重程度高且住院,在随后的所有波中发现充分免疫的人员没有住院危险(卡方值:87.04,p n = 3),心血管事件(n = 8),已有合并症恶化(n = 8)等。结论:这项研究证明了接种疫苗的好处而不是被感染的风险。本研究证明免疫接种影响COVID-19感染的并发症和住院率。这一证据可能有助于解决各国对疫苗的犹豫。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Therapeutic Advances in Vaccines and Immunotherapy
Therapeutic Advances in Vaccines and Immunotherapy Medicine-Pharmacology (medical)
CiteScore
5.10
自引率
0.00%
发文量
15
审稿时长
8 weeks
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