Olfactory Cleft Length: A Possible Risk Factor for Persistent Post-COVID-19 Olfactory Dysfunction.

IF 2 4区医学 Q2 OTORHINOLARYNGOLOGY

Orl-Journal for Oto-Rhino-Laryngology Head and Neck Surgery Pub Date : 2023-01-01 DOI:10.1159/000527141

Francisco Alves de Sousa, João Tarrio, André Sousa Machado, Joana Raquel Costa, Catarina Pinto, Ana Nóbrega Pinto, Bruno Moreira, Luís Meireles

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引用次数: 0

Abstract

Introduction: To date, little is known about predisposing factors for persistent COVID-19-induced olfactory dysfunction (pCIOD). The objective was to determine whether olfactory cleft (OC) measurements associate with pCIOD risk.

Material and methods: Three subgroups were recruited: group A included patients with pCIOD, group B included patients without olfactory dysfunction following SARS-CoV-2 infection (ntCIOD), and group C consisted in controls without past history of SARS-CoV-2 infection (noCOVID-19). Olfactory perception threshold (OPT) and visual analog scale for olfactory impairment (VAS-olf) were obtained. OC measurements were obtained through computed tomography scans. Results were subsequently compared.

Results: A total of 55 patients with a mean age of 39 ± 10 years were included. OPT was significantly lower in pCIOD patients (group A: 4.2 ± 2.1 vs. group B: 12.3 ± 1.8 and group C: 12.2 ± 1.5, p < 0.001). VAS-olf was significantly higher in pCIOD (group A: 6 ± 2.6 vs. group B: 1.7 ± 1.6 and group C: 1.6 ± 1.5, p < 0.001). OC length was significantly higher in group A (42.8 ± 4.6) compared to group B (39.7 ± 3.4, p = 0.047) and C (39.8 ± 4, p = 0.037). The odd of pCIOD occurring after COVID-19 infection increased by 21% (95% CI [0.981, 1.495]) for a one unit (mm) increase in OC length. The odd of pCIOD occurring was 6.9 times higher when OC length >40 mm.

Conclusion: Longer OC may be a predisposing factor for pCIOD. This study is expected to encourage further research on OC morphology and its impact on olfactory disorders.

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嗅裂长度:covid -19后持续嗅觉功能障碍的可能危险因素

迄今为止，对持续的covid -19诱导的嗅觉功能障碍(pCIOD)的易感因素知之甚少。目的是确定嗅裂(OC)测量是否与pCIOD风险相关。材料与方法:招募3个亚组:A组为pCIOD患者，B组为SARS-CoV-2感染后无嗅觉功能障碍患者(ntCIOD)， C组为无SARS-CoV-2感染史的对照组(noCOVID-19)。获得嗅觉知觉阈值(OPT)和视觉模拟嗅觉障碍量表(VAS-olf)。通过计算机断层扫描获得OC测量值。随后对结果进行比较。结果:共纳入55例患者，平均年龄39±10岁。pCIOD患者的OPT明显低于对照组(A组:4.2±2.1,B组:12.3±1.8,C组:12.2±1.5,p < 0.001)。pCIOD患者VAS-olf明显升高(A组为6±2.6,B组为1.7±1.6,C组为1.6±1.5,p < 0.001)。A组OC长度(42.8±4.6)明显高于B组(39.7±3.4,p = 0.047)和C组(39.8±4,p = 0.037)。每增加1个单位(mm)， COVID-19感染后发生pCIOD的几率增加21% (95% CI[0.981, 1.495])。当OC长度>40 mm时，发生pCIOD的几率高6.9倍。结论:OC长度较长可能是pCIOD的易感因素。该研究有望促进对OC形态及其对嗅觉障碍影响的进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Orl-Journal for Oto-Rhino-Laryngology Head and Neck Surgery 医学-耳鼻喉科学

CiteScore

2.80

自引率

7.70%

发文量

审稿时长

6-12 weeks

期刊介绍： ''ORL'' contains concise, original scientific papers of interest for both clinicians and researchers in oto-rhino-laryngology and head and neck surgery. Contributions drawn from the basic sciences cover new knowledge on the anatomy, pathology, pathophysiology, immunology and tumor biology of head and neck and the auditory and vestibular system, the salivary glands, paranasal sinuses and of the organs of the upper respiratory and digestive tract. The practical value of the journal is accentuated by reports of clinical progress in diagnosis and therapy.