Neurostimulation as a Putative Method for the Treatment of Drug-resistant Epilepsy in Patient and Animal Models of Epilepsy.

IF 1 Q4 NEUROSCIENCES

Basic and Clinical Neuroscience Pub Date : 2023-01-01 DOI:10.32598/bcn.2022.2360.4

Fatemeh Bakhtiarzadeh, Meysam Zare, Zahra Ghasemi, Samaneh Dehghan, Azam Sadeghin, Mohammad Taghi Joghataei, Nooshin Ahmadirad

引用次数: 0

Abstract

A patient with epilepsy was shown to have neurobiological, psychological, cognitive, and social issues as a result of recurring seizures, which is regarded as a chronic brain disease. However, despite numerous drug treatments, approximately, 30%-40% of all patients are resistant to antiepileptic drugs. Therefore, newer therapeutic modalities are introduced into clinical practice which involve neurostimulation and direct stimulation of the brain. Hence, we review published literature on vagus nerve stimulation, trigeminal nerve stimulation, applying responsive stimulation systems, and deep brain stimulation (DBS) in animals and epileptic patient with an emphasis on drug-resistant epilepsy.

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神经刺激作为治疗癫痫患者和癫痫动物模型中耐药性癫痫的一种假定方法。

一名癫痫患者因反复发作而出现神经生物学、心理、认知和社会问题，这被视为一种慢性脑部疾病。然而，尽管有许多药物治疗，大约30%-40%的患者对抗癫痫药物有耐药性。因此，新的治疗模式被引入临床实践，包括神经刺激和直接刺激大脑。因此，我们回顾了已发表的关于动物和癫痫患者迷走神经刺激、三叉神经刺激、应用反应性刺激系统和深部脑刺激（DBS）的文献，重点是耐药癫痫。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Basic and Clinical Neuroscience NEUROSCIENCES-

CiteScore

2.60

自引率

0.00%

发文量

审稿时长

4 weeks

期刊介绍： BCN is an international multidisciplinary journal that publishes editorials, original full-length research articles, short communications, reviews, methodological papers, commentaries, perspectives and “news and reports” in the broad fields of developmental, molecular, cellular, system, computational, behavioral, cognitive, and clinical neuroscience. No area in the neural related sciences is excluded from consideration, although priority is given to studies that provide applied insights into the functioning of the nervous system. BCN aims to advance our understanding of organization and function of the nervous system in health and disease, thereby improving the diagnosis and treatment of neural-related disorders. Manuscripts submitted to BCN should describe novel results generated by experiments that were guided by clearly defined aims or hypotheses. BCN aims to provide serious ties in interdisciplinary communication, accessibility to a broad readership inside Iran and the region and also in all other international academic sites, effective peer review process, and independence from all possible non-scientific interests. BCN also tries to empower national, regional and international collaborative networks in the field of neuroscience in Iran, Middle East, Central Asia and North Africa and to be the voice of the Iranian and regional neuroscience community in the world of neuroscientists. In this way, the journal encourages submission of editorials, review papers, commentaries, methodological notes and perspectives that address this scope.