Application of Localized Surface Plasmon Resonance of Conjugated Gold Nanoparticles in Spectral Diagnosis of SARS-CoV-2: A Numerical Study

IF 3.3 4区物理与天体物理 Q2 CHEMISTRY, PHYSICAL

Plasmonics Pub Date : 2023-06-10 DOI:10.1007/s11468-023-01901-1

Ehsan Koushki, Ali Asghar Mowlavi, Seyed Taha Hoseini

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引用次数: 0

Abstract

Severe respiratory syndrome COVID-19 (SARS-CoV-2) outbreak has became the most important global health issue, and simultaneous efforts to fast and low-cost diagnosis of this virus were performed by researchers. One of the most usual tests was colorimetric methods based on the change of color of gold nanoparticles in the presence of viral antibodies, antigens, and other biological agents. This spectral change can be due to the aggregation of the particles or the shift of localized surface plasmon resonance due to the electrical interactions of surface agents. It is known that surface agents could easily shift the absorption peak of metallic nanocolloids which is attributed to the localized surface plasmon resonance. Experimental diagnosis assays for colorimetric detection of SARS-CoV-2 using Au NPs were reviewed, and the shift of absorption peak was studied from the viewpoint of numerical analysis. Using the numerical method, the refractive index and real and imaginary parts of the effective relative permittivity of the viral biological shell around Au NPs were obtained. This model gives a quantitative description of colorimetric assays of the detection of SARS-CoV-2 using Au NPs.

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共轭金纳米粒子的局域表面等离子体共振在严重急性呼吸系统综合征冠状病毒2型光谱诊断中的应用：数值研究。

严重呼吸综合征新冠肺炎（SARS-CoV-2）的爆发已成为最重要的全球健康问题，研究人员同时努力快速、低成本地诊断这种病毒。最常见的测试之一是基于病毒抗体、抗原和其他生物制剂存在下金纳米颗粒颜色变化的比色方法。这种光谱变化可能是由于颗粒的聚集或由于表面剂的电相互作用而引起的局部表面等离子体共振的偏移。众所周知，表面试剂可以容易地改变金属纳米胶体的吸收峰，这归因于局部表面等离子体共振。综述了使用Au NPs比色检测严重急性呼吸系统综合征冠状病毒2型的实验诊断方法，并从数值分析的角度研究了吸收峰的移动。利用数值方法，获得了Au纳米粒子周围病毒生物外壳的折射率以及有效相对介电常数的实部和虚部。该模型对使用Au NPs检测严重急性呼吸系统综合征冠状病毒2型的比色分析进行了定量描述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Plasmonics 工程技术-材料科学：综合

CiteScore

5.90

自引率

6.70%

发文量

164

审稿时长

2.1 months

期刊介绍： Plasmonics is an international forum for the publication of peer-reviewed leading-edge original articles that both advance and report our knowledge base and practice of the interactions of free-metal electrons, Plasmons. Topics covered include notable advances in the theory, Physics, and applications of surface plasmons in metals, to the rapidly emerging areas of nanotechnology, biophotonics, sensing, biochemistry and medicine. Topics, including the theory, synthesis and optical properties of noble metal nanostructures, patterned surfaces or materials, continuous or grated surfaces, devices, or wires for their multifarious applications are particularly welcome. Typical applications might include but are not limited to, surface enhanced spectroscopic properties, such as Raman scattering or fluorescence, as well developments in techniques such as surface plasmon resonance and near-field scanning optical microscopy.