Early Environment and Telomeres: a Long-Term Toxic Relationship.

IF 7.4 2区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Current Environmental Health Reports Pub Date : 2023-06-01 Epub Date: 2023-03-22 DOI:10.1007/s40572-023-00395-7
José Francisco Herrera-Moreno, Diddier Prada, Andrea A Baccarelli
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引用次数: 0

Abstract

Purpose of review: Telomere length (TL) shortening is a hallmark of biological aging. While studies have extensively focused on the impact of environmental exposures on TL in older populations, consistent evidence indicates that prenatal environmental exposures to air pollutants, polycyclic aromatic hydrocarbons, metals, and endocrine-disrupting chemicals influence TL shortening. Here, we summarize evidence linking prenatal environmental exposures with children's TL and discuss potential long-term effects.

Recent findings: Current evidence shows that prenatal environmental exposures alter TL and identify pregnancy as a critical window of susceptibility for telomere damage in children. However, results vary across studies, possibly depending on the source, exposure time window, and stage evaluated. Additional research is needed to investigate whether early TL alterations mediate long-term health effects of offspring. Prenatal environmental exposures induce early childhood changes in TL. Based on known links between TL and biological aging, these alterations may have long-term impact on individuals' health throughout life.

早期环境与端粒:一种长期毒性关系。
综述目的:端粒长度缩短是生物衰老的标志。虽然研究广泛关注环境暴露对老年人群TL的影响,但一致的证据表明,产前环境暴露于空气污染物、多环芳烃、金属和内分泌干扰化学物质会影响TL的缩短。在这里,我们总结了将产前环境暴露与儿童TL联系起来的证据,并讨论了潜在的长期影响。最近的发现:目前的证据表明,产前环境暴露会改变TL,并将妊娠确定为儿童端粒损伤易感性的关键窗口。然而,研究结果各不相同,可能取决于来源、暴露时间窗口和评估阶段。需要进行更多的研究来调查早期TL的改变是否会对后代的长期健康产生影响。产前环境暴露会导致儿童早期TL的变化。基于TL与生物衰老之间的已知联系,这些变化可能会对个人一生的健康产生长期影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
13.60
自引率
1.30%
发文量
47
期刊介绍: Current Environmental Health Reports provides up-to-date expert reviews in environmental health. The goal is to evaluate and synthesize original research in all disciplines relevant for environmental health sciences, including basic research, clinical research, epidemiology, and environmental policy.
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