Biphasic drug release from electrospun structures.

IF 5 2区 医学 Q1 PHARMACOLOGY & PHARMACY
Expert Opinion on Drug Delivery Pub Date : 2023-05-01 Epub Date: 2023-05-08 DOI:10.1080/17425247.2023.2210834
Jianfeng Zhou, Pu Wang, Deng-Guang Yu, Yuanjie Zhu
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引用次数: 0

Abstract

Introduction: Biphasic release, as a special drug-modified release profile that combines immediate and sustained release, allows fast therapeutic action and retains blood drug concentration for long periods. Electrospun nanofibers, particularly those with complex nanostructures produced by multi-fluid electrospinning processes, are potential novel biphasic drug delivery systems (DDSs).

Areas covered: This review summarizes the most recent developments in electrospinning and related structures. In this review, the role of electrospun nanostructures in biphasic drug release was comprehensively explored. These electrospun nanostructures include monolithic nanofibers obtained through single-fluid blending electrospinning, core-shell and Janus nanostructures prepared via bifluid electrospinning, three-compartment nanostructures obtained via trifluid electrospinning, nanofibrous assemblies obtained through the layer-by-layer deposition of nanofibers, and the combined structure of electrospun nanofiber mats with casting films. The strategies and mechanisms through which complex structures facilitate biphasic release were analyzed.

Expert opinion: Electrospun structures can provide many strategies for the development of biphasic drug release DDSs. However, many issues such as the scale-up productions of complex nanostructures, the in vivo verification of the biphasic release effects, keeping pace with the developments of multi-fluid electrospinning, drawing support from the state-of-the-art pharmaceutical excipients, and the combination with traditional pharmaceutical methods need to be addressed for real applications.

电纺结构的双相药物释放。
简介双相释药是一种特殊的药物修饰释药方式,它结合了即释和缓释的特点,能够快速发挥治疗作用并长期保持血液中的药物浓度。电纺纳米纤维,尤其是通过多流体电纺工艺生产的具有复杂纳米结构的纳米纤维,是潜在的新型双相给药系统(DDS):本综述总结了电纺丝及相关结构的最新发展。本综述全面探讨了电纺纳米结构在双相释药中的作用。这些电纺纳米结构包括通过单流体混合电纺获得的单片纳米纤维、通过双流体电纺制备的核壳和 Janus 纳米结构、通过三流体电纺获得的三室纳米结构、通过纳米纤维逐层沉积获得的纳米纤维集合体,以及电纺纳米纤维毡与浇铸膜的组合结构。专家分析了复杂结构促进双相释放的策略和机制:电纺结构可为双相释药 DDS 的开发提供多种策略。然而,在实际应用中还需要解决许多问题,如复杂纳米结构的放大生产、体内双相释放效应的验证、与多流体电纺丝的发展保持同步、从最先进的药用辅料中汲取支持以及与传统制药方法的结合等。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
11.10
自引率
3.00%
发文量
104
审稿时长
3 months
期刊介绍: Expert Opinion on Drug Delivery (ISSN 1742-5247 [print], 1744-7593 [electronic]) is a MEDLINE-indexed, peer-reviewed, international journal publishing review articles covering all aspects of drug delivery research, from initial concept to potential therapeutic application and final relevance in clinical use. Each article is structured to incorporate the author’s own expert opinion on the scope for future development.
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