Extensive complex neocortical movement topography devolves to simple output following experimental stroke in mice.

IF 3.1 4区医学 Q2 NEUROSCIENCES

Frontiers in Systems Neuroscience Pub Date : 2023-06-07 eCollection Date: 2023-01-01 DOI:10.3389/fnsys.2023.1162664

Cassandra C Wolsh, Rogers Milton Brown, Andrew R Brown, Gilbert Andrew Pratt, Jeffery Allen Boychuk

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Abstract

The neocortex encodes complex and simple motor outputs in all mammalian species that have been tested. Given that changes in neocortical reorganization (and corresponding corticospinal output) have been implicated in long term motor recovery after stroke injury, there remains a need to understand this biology in order to expedite and optimize clinical care. Here, changes in the neocortical topography of complex and simple movement outputs were evaluated in mice following experimental middle cerebral artery occlusion (MCAo). Neocortical motor output was defined using long-duration parameters of intracortical microstimulation (LD-ICMS) based on area and spatial coordinates of separate motor output types to build upon our recent report in uninjured mice. LD-ICMS test sites that elicited complex (multi-joint) movement, simple (single skeletal joint) movement, as well as co-elicited FORELIMB + HINDLIMB responses were detected and recorded. Forelimb reaching behavior was assessed using the single pellet reaching (SPR) task. At 6 weeks post-surgery, behavioral deficits persisted and neocortical territories for separate movements exhibited differences in neocortical area, and spatial location, and differed between MCAo-Injured animals (i.e., the MCAo group) and Sham-Injured animals (i.e., the Control group). MCAo-Injury reduced neocortical area of complex movements while increasing area of simple movements. Limited effects of injury were detected for spatial coordinates of neocortical movements. Significant positive correlations were detected between final SPR performance and either area of complex retract or area of co-occurring FORELIMB + HINDLIMB sites.

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小鼠实验性中风后，广泛复杂的新皮质运动地形图转变为简单输出。

在所有经过测试的哺乳动物物种中，新皮层编码复杂和简单的运动输出。鉴于新皮质重组（和相应的皮质脊髓输出）的变化与脑卒中后的长期运动恢复有关，仍有必要了解这一生物学，以加快和优化临床护理。在这里，评估了实验性大脑中动脉闭塞（MCAo）后小鼠复杂和简单运动输出的新皮质地形图的变化。根据我们最近在未受伤小鼠中的报告，基于不同运动输出类型的面积和空间坐标，使用皮质内微刺激（LD-ICMS）的长期参数来定义新皮质运动输出。检测并记录引发复杂（多关节）运动、简单（单骨骼关节）运动以及共同引发FORELIMB+HINDLIMB反应的LD-ICMS测试位点。使用单颗粒触达（SPR）任务评估前臂触达行为。术后6周，行为缺陷持续存在，单独运动的新皮质区域在新皮质面积和空间位置上表现出差异，并且在MCAo损伤动物（即MCAo组）和Sham损伤动物（如对照组）之间也存在差异。MCAo损伤减少了复杂运动的新皮质面积，同时增加了简单运动的面积。新皮质运动的空间坐标检测到损伤的有限影响。在最终SPR性能与复杂回缩面积或同时存在的FORELIMB+HINDLIMB位点面积之间检测到显著的正相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Systems Neuroscience Neuroscience-Developmental Neuroscience

CiteScore

6.00

自引率

3.30%

发文量

144

审稿时长

14 weeks

期刊介绍： Frontiers in Systems Neuroscience publishes rigorously peer-reviewed research that advances our understanding of whole systems of the brain, including those involved in sensation, movement, learning and memory, attention, reward, decision-making, reasoning, executive functions, and emotions.