The tumour ecology of quiescence: Niches across scales of complexity

IF 12.1 1区医学 Q1 ONCOLOGY

Seminars in cancer biology Pub Date : 2023-07-01 DOI:10.1016/j.semcancer.2023.04.004

Simon P. Castillo , Felipe Galvez-Cancino , Jiali Liu , Steven M. Pollard , Sergio A. Quezada , Yinyin Yuan

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Abstract

Quiescence is a state of cell cycle arrest, allowing cancer cells to evade anti-proliferative cancer therapies. Quiescent cancer stem cells are thought to be responsible for treatment resistance in glioblastoma, an aggressive brain cancer with poor patient outcomes. However, the regulation of quiescence in glioblastoma cells involves a myriad of intrinsic and extrinsic mechanisms that are not fully understood. In this review, we synthesise the literature on quiescence regulatory mechanisms in the context of glioblastoma and propose an ecological perspective to stemness-like phenotypes anchored to the contemporary concepts of niche theory. From this perspective, the cell cycle regulation is multiscale and multidimensional, where the niche dimensions extend to extrinsic variables in the tumour microenvironment that shape cell fate. Within this conceptual framework and powered by ecological niche modelling, the discovery of microenvironmental variables related to hypoxia and mechanosignalling that modulate proliferative plasticity and intratumor immune activity may open new avenues for therapeutic targeting of emerging biological vulnerabilities in glioblastoma.

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静止的肿瘤生态学:跨越复杂尺度的生态位

静止是一种细胞周期停滞状态，使癌症细胞逃避抗增殖癌症治疗。静止的癌症干细胞被认为是胶质母细胞瘤治疗耐药性的原因，胶质母细胞癌是一种侵袭性癌症，患者预后不佳。然而，胶质母细胞瘤细胞静止期的调节涉及许多尚未完全理解的内在和外在机制。在这篇综述中，我们综合了胶质母细胞瘤背景下静止调节机制的文献，并根据生态位理论的当代概念，对干性样表型提出了生态学观点。从这个角度来看，细胞周期调控是多尺度和多维的，其中生态位维度延伸到肿瘤微环境中塑造细胞命运的外在变量。在这个概念框架内，在生态位建模的支持下，发现与缺氧和机械信号相关的微环境变量，调节增殖可塑性和肿瘤内免疫活性，可能为胶质母细胞瘤新出现的生物脆弱性的治疗靶向开辟新的途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Seminars in cancer biology 医学-肿瘤学

CiteScore

26.80

自引率

4.10%

发文量

347

审稿时长

15.1 weeks

期刊介绍： Seminars in Cancer Biology (YSCBI) is a specialized review journal that focuses on the field of molecular oncology. Its primary objective is to keep scientists up-to-date with the latest developments in this field. The journal adopts a thematic approach, dedicating each issue to an important topic of interest to cancer biologists. These topics cover a range of research areas, including the underlying genetic and molecular causes of cellular transformation and cancer, as well as the molecular basis of potential therapies. To ensure the highest quality and expertise, every issue is supervised by a guest editor or editors who are internationally recognized experts in the respective field. Each issue features approximately eight to twelve authoritative invited reviews that cover various aspects of the chosen subject area. The ultimate goal of each issue of YSCBI is to offer a cohesive, easily comprehensible, and engaging overview of the selected topic. The journal strives to provide scientists with a coordinated and lively examination of the latest developments in the field of molecular oncology.