Dose-sparing effect of Sabin-derived inactivated polio vaccine produced in Japan by intradermal injection device for rats

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-05-01 DOI:10.1016/j.biologicals.2023.101677

Eriko Itoh , Sakiko Shimizu , Yasushi Ami , Yoichiro Iwase , Yuichi Someya

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引用次数: 1

Abstract

The live-attenuated oral polio vaccine has long been used as the standard for polio prevention, but in order to minimize the emergence of pathogenic revertants, the inactivated polio vaccine (IPV), which is administered intramuscularly or subcutaneously, is being increasingly demanded worldwide. However, there is a global shortage of IPV, and its cost is an obstacle in developing countries. Therefore, dose-sparing with intradermal administration of IPV has been investigated. In this study, rats were immunized by intradermal (ID) and intramuscular (IM) administration of Sabin-derived inactivated polio vaccine (sIPV) produced in Japan, and the immune responses were evaluated. The results showed that one-fifth (1/5)-dose of ID administration yielded neutralizing antibody titers comparable to the full-dose IM administration, whereas 1/5-dose of IM administration was less effective than the full dose. Furthermore, a vertical puncture-type ID injection device (Immucise) that was originally developed for humans was modified for rats, resulting in successful and stable ID administration into the thin skin of rats. Based on these results, the ID administration of sIPV using Immucise in clinical use is expected to offer benefits such as reduced amounts of vaccine per dose, cost-effectiveness, and thereby the feasibility of vaccination for more people.

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大鼠皮内注射装置对日本产沙宾衍生脊髓灰质炎灭活疫苗的剂量节约效果

长期以来，口服脊髓灰质炎减毒活疫苗一直被用作预防脊髓灰质炎的标准，但为了最大限度地减少致病性回复体的出现，全世界对肌肉注射或皮下注射的脊髓灰质炎灭活疫苗（IPV）的需求越来越大。然而，全球IPV短缺，其成本在发展中国家是一个障碍。因此，对皮内注射IPV的剂量节省进行了研究。在本研究中，通过皮内（ID）和肌肉内（IM）给药日本生产的Sabin衍生的脊髓灰质炎灭活疫苗（sIPV）对大鼠进行免疫，并评估免疫反应。结果显示，五分之一（1/5）剂量的ID给药产生的中和抗体滴度与全剂量IM给药相当，而1/5剂量的IM给药的效果不如全剂量。此外，最初为人类开发的垂直穿刺型ID注射装置（Immunise）为大鼠进行了改进，成功且稳定地将ID注射到大鼠的薄皮中。基于这些结果，在临床使用中使用Immunise的sIPV ID给药有望带来益处，如减少每剂疫苗的数量、成本效益，从而为更多人接种疫苗提供可行性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.