The Efficacy of Olfactory Training as a Treatment for Olfactory Disorders Caused by Coronavirus Disease-2019: A Systematic Review and Meta-Analysis.

IF 2.5 3区医学 Q1 OTORHINOLARYNGOLOGY

American Journal of Rhinology & Allergy Pub Date : 2023-07-01 DOI:10.1177/19458924221150977

Se Hwan Hwang, Sung Won Kim, Mohammed Abdullah Basurrah, Do Hyun Kim

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引用次数: 5

Abstract

Background: There have been reports investigating the use of olfactory training in olfactory dysfunction after COVID-19.

Objective: We evaluated the effect of olfactory training on the olfactory dysfunction of patients infected with COVID-19.

Methods: We searched PubMed, EMBASE, the Web of Science, the Cochrane database, SCOPUS, and Google Scholar up to May 2022. We retrieved studies that compared the extents of olfactory dysfunction before and after olfactory training. We performed a subgroup analysis by the duration of olfactory dysfunction.

Results: The olfactory score after olfactory training (standard mean difference [SMD] = 1.0830, 95% confidence interval [CI] [0.6416; 1.5245], P < .0001, I² = 90.4%) was higher than that before training. The olfactory dysfunction rate differed significantly (OR = 0.0232, 95% CI [0.0052; 0.1044], P < .0001, I² = 63.1%) before and after olfactory training. On subgroup analysis, although patients with both acute (onset < 30 days prior) and chronic (onset > 30 days prior) olfactory dysfunction evidenced clinically significant improvements, training during acute dysfunction (compared to acute dysfunction) increased the olfactory score to a greater extent (SMD = 1.7779, 95% CI [1.0077; 2.5481] vs 0.6928 [0.2143; 1.1712], P = 0.0190). Moreover, as a result of subgroup analysis by dividing the included studies into2 using 2-month training period as standard, there was no statistically significant difference in the effect of the training period in the included study.

Conclusion: Olfactory training improved olfactory disorders caused by COVID-19. Such training was effective in both the acute and chronic phases.

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嗅觉训练治疗冠状病毒病-2019引起的嗅觉障碍的疗效:系统综述和荟萃分析

背景:有报道调查了嗅觉训练在COVID-19后嗅觉功能障碍中的应用。目的:探讨嗅觉训练对新型冠状病毒感染患者嗅觉功能障碍的影响。方法:截至2022年5月，我们检索了PubMed、EMBASE、Web of Science、Cochrane数据库、SCOPUS和Google Scholar。我们检索了比较嗅觉训练前后嗅觉功能障碍程度的研究。我们根据嗅觉功能障碍持续时间进行亚组分析。结果:嗅觉训练后的嗅觉评分(标准均差[SMD] = 1.0830, 95%可信区间[CI] [0.6416;[1.5245]， P < 0.0001, I2 = 90.4%)高于训练前。嗅觉功能障碍率差异有统计学意义(OR = 0.0232, 95% CI [0.0052;0.1044]， P < 0.0001, I2 = 63.1%)。在亚组分析中，尽管急性(发病前< 30天)和慢性(发病前> 30天)嗅觉功能障碍患者均有临床显著改善，但急性功能障碍期间的训练(与急性功能障碍相比)更大程度地增加了嗅觉评分(SMD = 1.7779, 95% CI [1.0077;2.5481] vs 0.6928 [0.2143;1.1712]， p = 0.0190)。此外，以2个月的训练期为标准将纳入研究分为2组进行亚组分析，纳入研究的训练期效果差异无统计学意义。结论:嗅觉训练可改善新冠肺炎患者的嗅觉障碍。这种训练在急性期和慢性期都是有效的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Rhinology & Allergy 医学-耳鼻喉科学

CiteScore

5.60

自引率

11.50%

发文量

审稿时长

4-8 weeks

期刊介绍： The American Journal of Rhinology & Allergy is a peer-reviewed, scientific publication committed to expanding knowledge and publishing the best clinical and basic research within the fields of Rhinology & Allergy. Its focus is to publish information which contributes to improved quality of care for patients with nasal and sinus disorders. Its primary readership consists of otolaryngologists, allergists, and plastic surgeons. Published material includes peer-reviewed original research, clinical trials, and review articles.