Biosynthesis of Gold Nanoparticles Using Quince Seed Water Extract and Investigation of Their Anticancer Effect Against Cancer Cell Lines

IF 3.7 4区生物学 Q1 BIOCHEMICAL RESEARCH METHODS

IEEE Transactions on NanoBioscience Pub Date : 2023-06-28 DOI:10.1109/TNB.2023.3287805

Mohammad Reza Ahmadpour;Mahdi Yousefi;Hassan Rakhshandeh;Majid Darroudi;Seyed Hadi Mousavi;Mohammad Soukhtanloo;Zahra Sabouri;Vahid Reza Askari;Alireza Hashemzadeh;Mohammad Azad Manjiri;Malihe Motavasselian

引用次数: 0

Abstract

In this study, gold nanoparticles (Au-NPs) were synthesized using HAuCl4 and quince seed mucilage (QSM) extract, which was characterized by conventional methods including Fourier transforms electron microscopy (FTIR), UV-Visible spectroscopy (UV-Vis), Field emission electron microscopy (FESEM), Transmission electron microscopy (TEM), Dynamic light spectroscopy (DLS), and Zeta-potential. The QSM acted as reductant and stabilizing agents simultaneously. The NP’s anticancer activity was also investigated against osteosarcoma cell lines (MG-63), which showed an IC50 of

$317 \mu \text{g}$

/mL.

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利用榅桲籽水提取物生物合成金纳米粒子并研究其对癌症细胞株的抗癌效果

本研究使用 HAuCl4 和榅桲籽粘液（QSM）提取物合成了金纳米粒子（Au-NPs），并通过傅立叶变换电子显微镜（FTIR）、紫外可见光谱（UV-Vis）、场发射电子显微镜（FESEM）、透射电子显微镜（TEM）、动态光光谱（DLS）和 Zeta 电位等传统方法对其进行了表征。QSM 同时起到还原剂和稳定剂的作用。还研究了 NP 对骨肉瘤细胞株 (MG-63) 的抗癌活性，结果显示其 IC50 为 [式中：见正文]/mL。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

IEEE Transactions on NanoBioscience 工程技术-纳米科技

CiteScore

7.00

自引率

5.10%

发文量

197

审稿时长

>12 weeks

期刊介绍： The IEEE Transactions on NanoBioscience reports on original, innovative and interdisciplinary work on all aspects of molecular systems, cellular systems, and tissues (including molecular electronics). Topics covered in the journal focus on a broad spectrum of aspects, both on foundations and on applications. Specifically, methods and techniques, experimental aspects, design and implementation, instrumentation and laboratory equipment, clinical aspects, hardware and software data acquisition and analysis and computer based modelling are covered (based on traditional or high performance computing - parallel computers or computer networks).