Deep phenotyping of pubertal development in Norwegian children: the Bergen Growth Study 2.

IF 1.2 4区医学 Q2 ANTHROPOLOGY

Annals of Human Biology Pub Date : 2023-02-01 DOI:10.1080/03014460.2023.2174272

Petur B Juliusson, Ingvild S Bruserud, Ninnie Helen Bakken Oehme, Andre Madsen, Ingvild H Forthun, Melissa Balthasar, Karen Rosendahl, Kristin Viste, Astanand Jugessur, Lawrence M Schell, Robert Bjerknes, Mathieu Roelants

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引用次数: 3

Abstract

Background: The Bergen Growth Study 2 (BGS2) aims to characterise somatic and endocrine changes in healthy Norwegian children using a novel methodology.

Subjects and methods: A cross-sectional sample of 1285 children aged 6-16 years was examined in 2016 using novel objective ultrasound assessments of breast developmental stages and testicular volume in addition to the traditional Tanner pubertal stages. Blood samples allowed for measurements of pubertal hormones, endocrine disruptive chemicals, and genetic analyses.

Results: Ultrasound staging of breast development in girls showed a high degree of agreement within and between observers, and ultrasound measurement of testicular volume in boys also showed small intra- and interobserver differences. The median age was 10.4 years for Tanner B2 (pubertal onset) and 12.7 years for menarche. Norwegian boys reached a pubertal testicular volume at a mean age of 11.7 years. Continuous reference curves for testicular volume and sex hormones were constructed using the LMS method.

Conclusions: Ultrasound-based assessments of puberty provided novel references for breast developmental stages and enabled the measurement of testicular volume on a continuous scale. Endocrine z-scores allowed for an intuitive interpretation of changing hormonal levels during puberty on a quantitative scale, which, in turn, provides opportunities for further analysis of pubertal development using machine-learning approaches.

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挪威儿童青春期发育的深层表型:卑尔根生长研究2。

背景:卑尔根生长研究2 (BGS2)旨在用一种新颖的方法描述健康挪威儿童的躯体和内分泌变化。对象与方法:2016年对1285名6-16岁儿童的横断面样本进行了检查，除了传统的Tanner青春期阶段外，还使用了新的客观超声评估乳房发育阶段和睾丸体积。血液样本可以用来测量青春期激素、内分泌干扰化学物质和基因分析。结果:女孩乳房发育的超声分期在观察者内部和观察者之间显示出高度的一致性，男孩睾丸体积的超声测量也显示出观察者内部和观察者之间的小差异。Tanner B2(青春期发病)的中位年龄为10.4岁，初潮的中位年龄为12.7岁。挪威男孩达到青春期睾丸体积的平均年龄为11.7岁。用LMS法构建睾丸体积和性激素的连续参考曲线。结论:基于超声的青春期评估为乳腺发育阶段提供了新的参考，并使睾丸体积的连续测量成为可能。内分泌z分数允许在定量尺度上直观地解释青春期激素水平的变化，这反过来又为使用机器学习方法进一步分析青春期发育提供了机会。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Human Biology 生物-公共卫生、环境卫生与职业卫生

CiteScore

3.40

自引率

5.90%

发文量

审稿时长

1 months

期刊介绍： Annals of Human Biology is an international, peer-reviewed journal published six times a year in electronic format. The journal reports investigations on the nature, development and causes of human variation, embracing the disciplines of human growth and development, human genetics, physical and biological anthropology, demography, environmental physiology, ecology, epidemiology and global health and ageing research.