Shared Transcriptional Control of Innate Lymphoid Cell and Dendritic Cell Development.

IF 11.4 1区生物学 Q1 CELL BIOLOGY

Annual review of cell and developmental biology Pub Date : 2019-10-06 Epub Date: 2019-07-05 DOI:10.1146/annurev-cellbio-100818-125403

Prachi Bagadia, Xiao Huang, Tian-Tian Liu, Kenneth M Murphy

引用次数: 0

Abstract

Innate immunity and adaptive immunity consist of highly specialized immune lineages that depend on transcription factors for both function and development. In this review, we dissect the similarities between two innate lineages, innate lymphoid cells (ILCs) and dendritic cells (DCs), and an adaptive immune lineage, T cells. ILCs, DCs, and T cells make up four functional immune modules and interact in concert to produce a specified immune response. These three immune lineages also share transcriptional networks governing the development of each lineage, and we discuss the similarities between ILCs and DCs in this review.

查看原文本刊更多论文

先天性淋巴细胞和树突状细胞发育的共同转录控制

先天性免疫和适应性免疫由高度特化的免疫系组成，它们的功能和发育都依赖于转录因子。在这篇综述中，我们将剖析先天性淋巴细胞（ILCs）和树突状细胞（DCs）这两个先天性免疫系与适应性免疫系 T 细胞之间的相似之处。先天性淋巴细胞、树突状细胞和 T 细胞组成了四个功能性免疫模块，它们相互作用，共同产生特定的免疫反应。这三个免疫系也共享转录网络，管理每个系的发育，我们将在这篇综述中讨论 ILC 和 DC 之间的相似之处。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Annual review of cell and developmental biology 生物-发育生物学

CiteScore

19.50

自引率

0.00%

发文量

期刊介绍： The Annual Review of Cell and Developmental Biology, established in 1985, comprehensively addresses major advancements in cell and developmental biology. Encompassing the structure, function, and organization of cells, as well as the development and evolution of cells in relation to both single and multicellular organisms, the journal explores models and tools of molecular biology. As of the current volume, the journal has transitioned from gated to open access through Annual Reviews' Subscribe to Open program, making all articles published under a CC BY license.