Hypomagnesemia in Patients With Cancer: The Forgotten Ion

IF 2.8 3区医学 Q2 UROLOGY & NEPHROLOGY

Seminars in nephrology Pub Date : 2022-11-01 DOI:10.1016/j.semnephrol.2023.151347

Marco Bonilla MD , Biruh T. Workeneh MD, FASN , Nupur N. Uppal MD

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引用次数: 1

Abstract

Magnesium is crucial for various cellular and enzymatic processes, yet it often is overlooked or underappreciated. Hypomagnesemia, a deficiency of magnesium in the blood, is a frequent problem in cancer patients and can lead to severe symptoms and morbidity. In this review, we provide an in-depth analysis of the physiology and regulation of magnesium, and signs and symptoms of hypomagnesemia in cancer patients. We also examine the causes and mechanisms of magnesium imbalances in cancer patients, specifically focusing on cancer-specific therapies that can lead to hypomagnesemia. Finally, we provide updates on the management of hypomagnesemia, including oral and parenteral supplementation, as well as the role of drugs in cases that are resistant to treatment. This review aims to raise awareness among health care providers caring for cancer patients about the significance of monitoring magnesium levels in cancer patients and function as a guide. Future clinical studies should focus on magnesium monitoring, its impact on cancer progression, and its potential for preventing acute kidney injury.

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癌症患者低镁血症:被遗忘的离子

镁对各种细胞和酶的过程至关重要，但它经常被忽视或低估。低镁血症是血液中镁的缺乏，是癌症患者的一个常见问题，可导致严重的症状和发病率。在这篇综述中，我们深入分析了镁的生理和调节，以及癌症患者低镁血症的体征和症状。我们还研究了癌症患者镁失衡的原因和机制，特别关注可能导致低镁血症的癌症特异性治疗。最后，我们提供了关于低镁血症管理的最新信息，包括口服和肠外补充，以及药物在治疗耐药病例中的作用。本综述旨在提高医疗保健提供者对癌症患者镁水平监测的重要性和指导作用的认识。未来的临床研究应该集中在镁的监测，它对癌症进展的影响，以及它预防急性肾损伤的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Seminars in nephrology 医学-泌尿学与肾脏学

CiteScore

5.60

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Seminars in Nephrology is a timely source for the publication of new concepts and research findings relevant to the clinical practice of nephrology. Each issue is an organized compendium of practical information that serves as a lasting reference for nephrologists, internists and physicians in training.