David Pezoa, Carlos J Blondel, Fernando A Amaya, Carlos A Santiviago
{"title":"Transfer of T6SS<sub>SPI-19</sub> from <i>Salmonella</i> Gallinarum to <i>Salmonella</i> Typhimurium Lacking T6SS<sub>SPI-6</sub> Complements its Colonization Defect in Mice.","authors":"David Pezoa, Carlos J Blondel, Fernando A Amaya, Carlos A Santiviago","doi":"10.33073/pjm-2023-017","DOIUrl":null,"url":null,"abstract":"<p><p><i>Salmonella</i> genus harbors five Type VI Secretion System (T6SS) gene clusters. The T6SS encoded in SPI-6 (T6SS<sub>SPI-6</sub>) contributes to <i>Salmonella</i> Typhimurium colonization of chickens and mice, while the T6SS encoded in SPI-19 (T6SS<sub>SPI-19</sub>) of <i>Salmonella</i> Gallinarum contributes to chicken colonization. Interestingly, the T6SS<sub>SPI-19</sub> of <i>Salmonella</i> Gallinarum complemented the defect in chicken colonization of a <i>Salmonella</i> Typhimurium strain that lacks the T6SS<sub>SPI-6</sub>, suggesting that both T6SSs are interchangeable. Here we show that the transfer of <i>Salmonella</i> Gallinarum T6SS<sub>SPI-19</sub> complemented the defect in mice colonization of a <i>Salmonella</i> Typhimurium ΔT6SS<sub>SPI-6</sub> strain, indicating that both T6SSs are functionally redundant during host colonization.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":null,"pages":null},"PeriodicalIF":4.6000,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1c/e1/pjm-72-2-pjm-2023-017.PMC10266286.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Bio Materials","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.33073/pjm-2023-017","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
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Abstract
Salmonella genus harbors five Type VI Secretion System (T6SS) gene clusters. The T6SS encoded in SPI-6 (T6SSSPI-6) contributes to Salmonella Typhimurium colonization of chickens and mice, while the T6SS encoded in SPI-19 (T6SSSPI-19) of Salmonella Gallinarum contributes to chicken colonization. Interestingly, the T6SSSPI-19 of Salmonella Gallinarum complemented the defect in chicken colonization of a Salmonella Typhimurium strain that lacks the T6SSSPI-6, suggesting that both T6SSs are interchangeable. Here we show that the transfer of Salmonella Gallinarum T6SSSPI-19 complemented the defect in mice colonization of a Salmonella Typhimurium ΔT6SSSPI-6 strain, indicating that both T6SSs are functionally redundant during host colonization.
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