Surgical results of only antegrade del Nido cardioplegia infusion in conventional coronary artery bypass grafting: a retrospective study.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-11-01 Epub Date: 2023-06-28 DOI:10.12701/jyms.2023.00283

Sang-Uk Park, Yo Han Bae, Yun Seok Kim, Kyungsub Song, Woo Sung Jang

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引用次数: 0

Abstract

Background: Additional retrograde cardioplegia infusion in conventional coronary artery bypass grafting (CABG) was introduced to address the concern of inappropriate cardioplegia delivery through the stenotic coronary artery. However, this method is complex and requires repeated infusions. Therefore, we investigated the surgical outcomes of only antegrade cardioplegia infusion in conventional CABG.

Methods: We included 224 patients who underwent isolated CABG between 2017 and 2019. The patients were divided into two groups according to the cardioplegia infusion method: antegrade cardioplegia infusion with del Nido solution (n=111, group I) and antegrade+retrograde cardioplegia infusion with blood cardioplegia solution (n=113, group II).

Results: The sinus recovery time after release of the aorta cross-clamp was shorter in group I (3.8±7.1 minutes, n=98) than in group II (5.8±4.1 minutes, n=73) (p=0.033). The total cardioplegia infusion volume was lower in group I (1,998.6±668.6 mL) than in group II (7,321.0±2,865.3 mL) (p<0.001). Creatine kinase-MB levels were significantly lower in group I than in group II (p=0.039). Newly developed regional wall motion abnormalities on follow-up echocardiography were detected in two patients (1.8%) in group I and five patients (4.4%) in group II (p=0.233). There was no significant difference in ejection fraction improvement between the two groups (3.3%±9.3% in group I and 3.3%±8.7% in group II, p=0.990).

Conclusion: The only antegrade cardioplegia infusion strategy in conventional CABG is safe and has no harmful effects.

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传统冠状动脉旁路移植术中仅顺行del Nido停搏液输注的手术效果:回顾性研究。

背景:在传统的冠状动脉旁路移植术(CABG)中引入额外的逆行心脏骤停输液，以解决通过狭窄的冠状动脉不适当的心脏骤停输送的问题。然而，这种方法很复杂，需要反复注射。因此，我们研究了常规冠脉搭桥中仅顺行灌注停搏液的手术效果。方法:我们纳入了2017年至2019年期间接受孤立CABG的224例患者。根据停搏液输注方式将患者分为顺行灌注del Nido停搏液组(n=111，ⅰ组)和顺行+逆行灌注血停搏液组(n=113，ⅱ组)。结果:ⅰ组解除主动脉交叉夹后窦恢复时间(3.8±7.1 min, n=98)短于ⅱ组(5.8±4.1 min, n=73) (p=0.033)。ⅰ组停搏液总输注量(1,998.6±668.6 mL)低于ⅱ组(7,321.0±2,865.3 mL) (p结论:常规冠脉搭桥中唯一顺行停搏液输注策略是安全的，无不良反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.