Critical elements in tissue engineering of craniofacial malformations.

IF 2.4 4区 医学 Q4 CELL & TISSUE ENGINEERING
Ali Gholamalizadeh, Sajed Nazifkerdar, Nasim Safdarian, Aida Eyvaz Ziaee, Hamid Mobedi, Reza Rahbarghazi, Mehdi Khanmohammadi, Sepideh Saghati
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引用次数: 0

Abstract

Abnormal craniofacial bone fusion can lead to the generation of several congenital malformations such as cleft palate, craniosynostosis and craniofacial skeletal hypoplasia, which physically and mentally affect patients. Conventional approaches for the treatment of craniofacial malformations such as the transplantation of autologous bone grafts are not completely efficient and usually, patients suffer from various complications. In line with these statements, the advent of novel therapeutic approaches in human medicine is mandatory. Regarding the extent, size and severity of the bone malformation, supplementation and release of oxygen molecules into the affected sites are critical issues for successful osteogenesis. Here, tissue engineering modalities associated with oxygen supplementation and novel approaches associated with hydrogel synthesis were highlighted in terms of craniofacial malformations.

颅面畸形组织工程的关键因素。
颅面骨融合异常可导致腭裂、颅缝闭锁、颅面骨发育不全等几种先天性畸形的产生,对患者身心造成影响。传统的颅面畸形治疗方法如自体骨移植并不完全有效,而且患者通常会出现各种并发症。与这些声明一致,人类医学中出现新的治疗方法是强制性的。考虑到骨畸形的程度、大小和严重程度,氧分子的补充和释放是成功成骨的关键问题。在颅面畸形方面,强调了与氧气补充相关的组织工程模式和与水凝胶合成相关的新方法。
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来源期刊
Regenerative medicine
Regenerative medicine 医学-工程:生物医学
CiteScore
4.20
自引率
3.70%
发文量
82
审稿时长
6-12 weeks
期刊介绍: Regenerative medicine replaces or regenerates human cells, tissue or organs, to restore or establish normal function*. Since 2006, Regenerative Medicine has been at the forefront of publishing the very best papers and reviews covering the entire regenerative medicine sector. The journal focusses on the entire spectrum of approaches to regenerative medicine, including small molecule drugs, biologics, biomaterials and tissue engineering, and cell and gene therapies – it’s all about regeneration and not a specific platform technology. The journal’s scope encompasses all aspects of the sector ranging from discovery research, through to clinical development, through to commercialization. Regenerative Medicine uniquely supports this important area of biomedical science and healthcare by providing a peer-reviewed journal totally committed to publishing the very best regenerative medicine research, clinical translation and commercialization. Regenerative Medicine provides a specialist forum to address the important challenges and advances in regenerative medicine, delivering this essential information in concise, clear and attractive article formats – vital to a rapidly growing, multidisciplinary and increasingly time-constrained community. Despite substantial developments in our knowledge and understanding of regeneration, the field is still in its infancy. However, progress is accelerating. The next few decades will see the discovery and development of transformative therapies for patients, and in some cases, even cures. Regenerative Medicine will continue to provide a critical overview of these advances as they progress, undergo clinical trials, and eventually become mainstream medicine.
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