Application of Barophoresis in Chronic Generalized Periodontitis: a Mathematical Substantiation.

IF 1.1 Q4 MEDICINE, RESEARCH & EXPERIMENTAL
I I Antonov, A B Dymnikov, A A Muraev, L A Ananyeva, S Yu Ivanov
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引用次数: 0

Abstract

The aim of the study was to evaluate the use of barophoresis for the delivery of liquid-air drug substances to the gums using a mathematical model of the interaction of the drug mixture with periodontal tissues.

Materials and methods: The solution to the problem was preceded by generation of a geometric CAD model of the device and nozzle for barophoresis, including the nozzle and injector geometry. The Ansys SpaceClaim software package was used to generate the CAD geometry.

Results: When solving the problem of finding the optimal distance from the nozzle to the gum surface, the numerical modeling showed that at a distance of 5 mm, the volume fraction of liquid in the mixture is 18-20%. The mixture actually breaks through the gum, filling 0.8 mm of the gum thickness and spreading symmetrically to the sides at a distance of up to 3 cm, forming a cavity. At a distance of 10 mm from the nozzle to the gum surface, the liquid volume fraction in the mixture close to the gum lies in a narrow range of values of 5 to 7%. The mixture touches the surface of the gums, penetrating slightly - at a distance of 0.30-0.45 mm. At a distance of 15 mm from the nozzle to the gum surface, the volume fraction of liquid in the mixture near the gum lies in the range of 2-5%. The mixture slightly touches the gum surface, getting inside at a distance of up to 0.2 mm, having practically no effect on the gum.

Conclusion: The developed mathematical model confirmed the feasibility of application of barophoresis in the treatment of chronic generalized periodontitis. The optimal distance from the nozzle to the surface should be considered to be 10-15 mm. This distance is safe and allows the drug delivery to a depth of 0.45 mm.

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空气电泳在慢性广泛性牙周炎中的应用:一个数学实证。
该研究的目的是利用药物混合物与牙周组织相互作用的数学模型来评估气压电泳在将液体-空气药物物质输送到牙龈中的应用。材料和方法:在解决该问题之前,首先生成了用于气压电泳的装置和喷嘴的几何CAD模型,包括喷嘴和注射器的几何形状。利用Ansys spacecclaim软件包生成CAD几何图形。结果:在解决喷嘴到胶表面的最佳距离问题时,数值模拟显示,在5 mm的距离下,混合物中液体的体积分数为18-20%。这种混合物实际上穿过了牙龈,填满了0.8毫米厚的牙龈,并以3厘米的距离对称地向两边扩散,形成了一个空腔。在喷嘴距离树胶表面10mm处,靠近树胶的混合物中液体体积分数在5 ~ 7%的狭窄范围内。混合物接触牙龈表面,在0.30-0.45毫米的距离上略微穿透。在喷嘴距离胶表面15mm处,胶附近混合物中液体的体积分数为2-5%。混合物稍微接触到口香糖表面,在0.2毫米的距离内进入,对口香糖几乎没有影响。结论:建立的数学模型证实了吸痰治疗慢性广泛性牙周炎的可行性。从喷嘴到表面的最佳距离应考虑为10-15毫米。这个距离是安全的,并且允许药物输送到0.45 mm的深度。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Sovremennye Tehnologii v Medicine
Sovremennye Tehnologii v Medicine MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
1.80
自引率
0.00%
发文量
38
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