The relationship between cortisol awakening response and trait resilience in two patient cohorts and one population-based cohort.

IF 3 4区医学 Q2 PSYCHIATRY

World Journal of Biological Psychiatry Pub Date : 2023-06-01 DOI:10.1080/15622975.2022.2129445

Patrick Linnemann, Nele Friedrich, Matthias Nauck, Henning Teismann, Klaus Berger

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引用次数: 1

Abstract

Objectives: We examined (1) the proportion of cortisol awakening non-responders, (2) the association between cortisol awakening response (CAR) and trait resilience, and (3) the association between CAR increase and trait resilience in two patient cohorts (depression and myocardial infarction [CVD]) and one population-based cohort.

Methods: Eight hundred and eighty study participants delivered CAR scores (response and increase) based on three self-collected saliva samples and a trait resilience score. Descriptive data of CAR non-responders were reported and calculated. Associations between CAR response/increase and trait resilience, sociodemographic and compliance variables were evaluated using multiple logistic and multiple linear regression analyses stratified by cohort.

Results: The proportion of CAR non-responders was high in all cohorts (57% depression cohort, 53.4% CVD cohort, 51.6% control cohort). In the depression cohort age was associated with CAR response and increase. In the CVD cohort salivary collection on a weekday was associated with CAR response and awakening time with CAR increase. In the control cohort age was associated with CAR response and sex with CAR increase.

Conclusions: We observed many CAR non-responders and significant associations between CAR response and CAR increase with single sociodemographic and compliance variables. We did not find significant relationships between CAR response or increase and trait resilience.

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在两个患者队列和一个基于人群的队列中，皮质醇唤醒反应与特质恢复力之间的关系。

目的:我们在两个患者队列(抑郁症和心肌梗死[CVD])和一个基于人群的队列中研究了(1)皮质醇觉醒无应答者的比例，(2)皮质醇觉醒反应(CAR)与特质恢复力之间的关联，以及(3)CAR升高与特质恢复力之间的关联。方法:880名研究参与者根据三份自我收集的唾液样本和一份特质弹性评分提供了CAR评分(反应和增加)。报告并计算CAR无应答者的描述性数据。采用队列分层的多重逻辑和多重线性回归分析评估CAR反应/增加与特质弹性、社会人口统计学和依从性变量之间的关系。结果:CAR无应答者的比例在所有队列中都很高(抑郁症队列57%，心血管疾病队列53.4%，对照队列51.6%)。在抑郁症队列中，年龄与CAR反应和增加有关。在心血管疾病队列中，工作日唾液采集与CAR反应有关，唤醒时间与CAR增加有关。在对照队列中，年龄与CAR反应相关，性别与CAR升高相关。结论:我们观察到许多CAR无应答者，并且在单个社会人口统计学和依从性变量中，CAR应答和CAR增加之间存在显著关联。我们没有发现CAR反应或增加与特质弹性之间的显著关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

World Journal of Biological Psychiatry 医学-精神病学

CiteScore

7.00

自引率

3.20%

发文量

审稿时长

6-12 weeks

期刊介绍： The aim of The World Journal of Biological Psychiatry is to increase the worldwide communication of knowledge in clinical and basic research on biological psychiatry. Its target audience is thus clinical psychiatrists, educators, scientists and students interested in biological psychiatry. The composition of The World Journal of Biological Psychiatry , with its diverse categories that allow communication of a great variety of information, ensures that it is of interest to a wide range of readers. The World Journal of Biological Psychiatry is a major clinically oriented journal on biological psychiatry. The opportunity to educate (through critical review papers, treatment guidelines and consensus reports), publish original work and observations (original papers and brief reports) and to express personal opinions (Letters to the Editor) makes The World Journal of Biological Psychiatry an extremely important medium in the field of biological psychiatry all over the world.