Telomere length and mitochondrial DNA copy number in bipolar disorder: A sibling study.

IF 3 4区医学 Q2 PSYCHIATRY

World Journal of Biological Psychiatry Pub Date : 2023-06-01 DOI:10.1080/15622975.2022.2131907

Luana Spano, Bruno Etain, Jean-Louis Laplanche, Marion Leboyer, Sébastien Gard, Frank Bellivier, Cynthia Marie-Claire

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引用次数: 0

Abstract

Objectives: An accelerated cellular ageing has been observed in bipolar disorder (BD) using biomarkers such as telomere length (TL) and mitochondrial DNA copy number (mtDNAcn). Several risk factors might drive premature ageing in individuals with BD, including a familial predisposition. This study compared TL and mtDNAcn between individuals with BD and their (un)-affected siblings, and explored factors that may explain proband-sibling differences.

Methods: Sixty individuals with BD and seventy-four siblings (34 affected with BD or mood disorders and 40 unaffected) were included. Quantitative polymerase chain reaction (qPCR) was used to measure TL and mtDNAcn from peripheral blood genomic DNA.

Results: TL and mtDNAcn did not significantly differ between probands and their siblings, whatever these latter were affected or not with mood disorders. However, the correlation plots of TL or mtDNAcn in proband-sibling pairs suggested that some pairs were discordant. The within proband-sibling pairs differences for TL and mtDNAcn were not explained by differences in all tested factors.

Conclusions: This study shows that probands with BD and their siblings are concordant for TL and mtDNAcn suggesting that they may share some environmental or genetic determinants of these two biomarkers of cellular ageing.

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双相情感障碍的端粒长度和线粒体DNA拷贝数:一项同胞研究。

目的:利用端粒长度(TL)和线粒体DNA拷贝数(mtDNAcn)等生物标志物，观察到双相情感障碍(BD)患者细胞衰老加速。一些风险因素可能导致双相障碍患者过早衰老，包括家族易感性。本研究比较了双相障碍患者及其(未)患病兄弟姐妹之间的TL和mtDNAcn，并探讨了可能解释先证兄弟姐妹差异的因素。方法:纳入60名双相障碍患者和74名兄弟姐妹(34名患有双相障碍或情绪障碍，40名未患双相障碍)。采用定量聚合酶链反应(qPCR)测定外周血基因组DNA的TL和mtDNAcn。结果:先证及其兄弟姐妹之间TL和mtDNAcn无显著差异，无论后者是否受情绪障碍影响。然而，先证-兄弟姐妹对TL或mtDNAcn的相关图显示，有些对是不一致的。在先证者-兄弟姐妹之间TL和mtDNAcn的差异不能用所有测试因素的差异来解释。结论:本研究表明，BD先证及其兄弟姐妹在TL和mtDNAcn上是一致的，这表明他们可能共享这两种细胞衰老生物标志物的一些环境或遗传决定因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

World Journal of Biological Psychiatry 医学-精神病学

CiteScore

7.00

自引率

3.20%

发文量

审稿时长

6-12 weeks

期刊介绍： The aim of The World Journal of Biological Psychiatry is to increase the worldwide communication of knowledge in clinical and basic research on biological psychiatry. Its target audience is thus clinical psychiatrists, educators, scientists and students interested in biological psychiatry. The composition of The World Journal of Biological Psychiatry , with its diverse categories that allow communication of a great variety of information, ensures that it is of interest to a wide range of readers. The World Journal of Biological Psychiatry is a major clinically oriented journal on biological psychiatry. The opportunity to educate (through critical review papers, treatment guidelines and consensus reports), publish original work and observations (original papers and brief reports) and to express personal opinions (Letters to the Editor) makes The World Journal of Biological Psychiatry an extremely important medium in the field of biological psychiatry all over the world.