Age Differences in Upper Gastrointestinal Symptoms and Vagal Modulation in Women With Irritable Bowel Syndrome.

IF 1.9 4区医学 Q2 NURSING

Biological research for nursing Pub Date : 2024-01-01 Epub Date: 2023-06-23 DOI:10.1177/10998004231186188

Li Juen Chen, Robert Burr, Kevin Cain, Kendra Kamp, Margaret Heitkemper

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引用次数: 0

Abstract

Background/aims: Patients with irritable bowel syndrome (IBS) often report upper gastrointestinal (GI) (e.g., nausea and heartburn), somatic, and emotional symptoms. This study seeks to examine the relationships among younger and older women with IBS and indicators of autonomic nervous system (ANS) function and daily nausea and heartburn symptoms.

Methods: Women were recruited through clinics and the community. Nocturnal heart rate variability (HRV) was obtained using ambulatory electrocardiogram Holter monitors. Individual symptom severity and frequency were collected using 28-day diaries. All variables were stratified by younger (<46 years) and older (≥46 years) age groups.

Results: Eighty-nine women with IBS were included in this descriptive correlation study (n = 57 younger; n = 32 older). Older women had reduced indices of vagal activity when compared to younger women. In older women, there was an inverse correlation between nausea and vagal measures (Ln RMSSD, r = -.41, p = .026; Ln pNN50, r = -.39, p = .034). Heartburn in older women was associated with sleepiness (r = .59, p < .001) and anger (r = .48, p = .006). Nausea was significantly correlated with anger in the younger group (r = .41, p = .001). There were no significant relationships between HRV indicators and nausea and heartburn in younger women.

Conclusions: Age-related differences in ANS function that are associated with nausea may portend unique opportunities to better understand the vagal dysregulation in women with IBS.

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肠易激综合征女性上消化道症状和迷走神经调节的年龄差异

背景/目的:肠易激综合征(IBS)患者经常报告上胃肠道(GI)(如恶心和胃灼热)、躯体和情绪症状。本研究旨在探讨年轻和老年妇女肠易激综合征与自主神经系统(ANS)功能指标和每日恶心和胃灼热症状之间的关系。方法:通过诊所和社区招募妇女。夜间心率变异性(HRV)通过动态心电图动态心电图仪获得。用28天日记收集个体症状严重程度和频率。结果:89名患有肠易激综合征的女性纳入了这项描述性相关研究(n = 57名年轻;N = 32)。与年轻女性相比，老年女性迷走神经活动指数降低。在老年妇女中，恶心和迷走神经测量呈负相关(Ln RMSSD, r = -)。41, p = 0.026;Ln pNN50 r = -。39, p = 0.034)。老年妇女的胃灼热与嗜睡(r = 0.59, p < 0.001)和愤怒(r = 0.48, p = 0.006)有关。年轻组的恶心与愤怒显著相关(r = .41, p = .001)。在年轻女性中，HRV指标与恶心和胃灼热之间没有显著的关系。结论:与恶心相关的年龄相关性ANS功能差异可能预示着更好地了解IBS女性迷走神经失调的独特机会。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biological research for nursing 医学-护理

CiteScore

5.10

自引率

4.00%

发文量

审稿时长

>12 weeks

期刊介绍： Biological Research For Nursing (BRN) is a peer-reviewed quarterly journal that helps nurse researchers, educators, and practitioners integrate information from many basic disciplines; biology, physiology, chemistry, health policy, business, engineering, education, communication and the social sciences into nursing research, theory and clinical practice. This journal is a member of the Committee on Publication Ethics (COPE)