Association between PLA2 gene polymorphisms and treatment response to antipsychotic medications: A study of antipsychotic-naïve first-episode psychosis patients and nonadherent chronic psychosis patients

IF 3
Sergej Nadalin , Lena Zatković , Vjekoslav Peitl , Dalibor Karlović , Branka Vidrih , Antonia Puljić , Sanja Dević Pavlić , Alena Buretić-Tomljanović
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引用次数: 0

Abstract

Here we investigated whether antipsychotic treatment was influenced by three polymorphisms: rs10798059 (BanI) in the phospholipase A2 (PLA2)G4A gene, rs4375 in PLA2G6, and rs1549637 in PLA2G4C. A total of 186 antipsychotic-naïve first-episode psychosis patients or nonadherent chronic psychosis individuals (99 males and 87 females) were genotyped by polymerase chain reaction analysis/restriction fragment length polymorphism. At baseline, and after 8 weeks of treatment with various antipsychotic medications, we assessed patients’ Positive and Negative Syndrome Scale (PANSS) scores, PANSS factors, and metabolic syndrome-related parameters (fasting plasma lipid and glucose levels, and body mass index). We found that PLA2G4A polymorphism influenced changes in PANSS psychopathology, and PLA2G6 polymorphism influenced changes in PANSS psychopathology and metabolic parameters. PLA2G4C polymorphism did not show any impact on PANSS psychopathology or metabolic parameters. The polymorphisms’ effect sizes were estimated as moderate to strong, with contributions ranging from around 6.2–15.7%. Furthermore, the polymorphisms’ effects manifested in a gender-specific manner.

PLA2基因多态性与抗精神病药物治疗反应之间的关系:antipsychotic-naïve首发精神病患者和非依从性慢性精神病患者的研究
在这里,我们研究了抗精神病药物治疗是否受到三种多态性的影响:磷脂酶A2(PLA2)G4A基因中的rs10798059(BanI)、PLA2G6中的rs4375和PLA2G4C中的rs1549637。采用聚合酶链反应分析/限制性片段长度多态性对186名抗精神病药物幼稚首发精神病患者或非粘附性慢性精神病患者(99名男性和87名女性)进行基因分型。在基线时,以及在使用各种抗精神病药物治疗8周后,我们评估了患者的阳性和阴性综合征量表(PANSS)评分、PANSS因素和代谢综合征相关参数(空腹血脂和血糖水平以及体重指数)。我们发现PLA2G4A多态性影响PANSS精神病理学的变化,PLA2G6多态性影响PANSS精神病理学和代谢参数的变化。PLA2G4C多态性对PANSS精神病理学或代谢参数没有任何影响。多态性的效应大小估计为中等到强烈,贡献率在6.2-15.7%之间。此外,多态性的影响以特定性别的方式表现出来。
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来源期刊
Prostaglandins, leukotrienes, and essential fatty acids
Prostaglandins, leukotrienes, and essential fatty acids Clinical Biochemistry, Endocrinology, Diabetes and Metabolism
CiteScore
5.30
自引率
0.00%
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0
审稿时长
64 days
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