Anesthetic effects of isoflurane and fentanyl infusion in capuchin monkeys (Sapajus sp) undergoing salpingectomy or deferentectomy, previously chemically restrained with ketamine–midazolam or ketamine–dexmedetomidine

IF 0.8 4区农林科学 Q3 VETERINARY SCIENCES

Journal of Medical Primatology Pub Date : 2023-03-13 DOI:10.1111/jmp.12639

Viviane Horta Gomes, Mayara Muniz Freitas, Thuane do Nascimento Morais, Thiago Queiroz de Menezes, Anieli Vidal Stocco, Marcela de Oliveira Loureiro da Silva, Daniel de Almeida Balthazar

{"title":"Anesthetic effects of isoflurane and fentanyl infusion in capuchin monkeys (Sapajus sp) undergoing salpingectomy or deferentectomy, previously chemically restrained with ketamine–midazolam or ketamine–dexmedetomidine","authors":"Viviane Horta Gomes, Mayara Muniz Freitas, Thuane do Nascimento Morais, Thiago Queiroz de Menezes, Anieli Vidal Stocco, Marcela de Oliveira Loureiro da Silva, Daniel de Almeida Balthazar","doi":"10.1111/jmp.12639","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>This study evaluated the anesthetic and cardiorespiratory effects of two anesthetic protocols for salpingectomy or deferentectomy in capuchin monkeys (<i>Sapajus sp</i>).</p>\n </section>\n \n <section>\n \n <h3> Materials and Methods</h3>\n \n <p>Five capuchin monkeys (5 per group) received ketamine (20 mg/kg) combined with midazolam (0.5 mg/kg; group KM) or dexmedetomidine (5 μg/kg; group KD) intramuscularly. Anesthesia is induced with propofol intravenously and maintained with isoflurane. Before the start of surgery, fentanyl 3 μg/kg was administered IV, and continuous infusion (10 μg/kg/min) IV was started. Times and quality of anesthetic recovery were evaluated postoperatively.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>KM and KD resulted in adequate chemical restraint. KD resulted in bradycardia. Intraoperative heart rate and systolic blood pressure were higher in KM than in KD. Both groups had smooth recovery. Time to standing was longer in KM than in KD.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Both protocols allowed the performance of surgeries, with few cardiorespiratory effects. Anesthetic recovery was smooth and shorter in KD group.</p>\n </section>\n </div>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"52 3","pages":"149-155"},"PeriodicalIF":0.8000,"publicationDate":"2023-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Medical Primatology","FirstCategoryId":"97","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/jmp.12639","RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

Background

This study evaluated the anesthetic and cardiorespiratory effects of two anesthetic protocols for salpingectomy or deferentectomy in capuchin monkeys (Sapajus sp).

Materials and Methods

Five capuchin monkeys (5 per group) received ketamine (20 mg/kg) combined with midazolam (0.5 mg/kg; group KM) or dexmedetomidine (5 μg/kg; group KD) intramuscularly. Anesthesia is induced with propofol intravenously and maintained with isoflurane. Before the start of surgery, fentanyl 3 μg/kg was administered IV, and continuous infusion (10 μg/kg/min) IV was started. Times and quality of anesthetic recovery were evaluated postoperatively.

Results

KM and KD resulted in adequate chemical restraint. KD resulted in bradycardia. Intraoperative heart rate and systolic blood pressure were higher in KM than in KD. Both groups had smooth recovery. Time to standing was longer in KM than in KD.

Conclusion

Both protocols allowed the performance of surgeries, with few cardiorespiratory effects. Anesthetic recovery was smooth and shorter in KD group.

查看原文本刊更多论文

异氟醚和芬太尼输注在进行输卵管切除术或输精管切除术的卷尾猴(Sapajus sp)的麻醉效果，先前用氯胺酮-咪达唑仑或氯胺酮-右美托咪定进行化学抑制

背景本研究评估了两种麻醉方案对卷尾猴输卵管切除术或输精管切除术的麻醉和心肺效果。材料和方法5只卷尾猴（每组5只）接受氯胺酮（20 mg/kg）与咪达唑仑（0.5 mg/kg；KM组）或右美托咪定（5 μg/kg；KD组）肌肉注射。丙泊酚静脉内麻醉，异氟醚维持麻醉。手术开始前，芬太尼3 静脉注射μg/kg，并持续输注（10 μg/kg/min）静脉注射。术后评估麻醉恢复的时间和质量。结果KM和KD具有足够的化学抑制作用。KD导致心动过缓。KM组术中心率和收缩压均高于KD组。两组患者均恢复顺利。KM的站立时间比KD长。结论两种方案都允许进行手术，心肺功能几乎没有影响。KD组麻醉恢复平稳、时间短。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Medical Primatology 生物-动物学

CiteScore

1.40

自引率

42.90%

发文量

审稿时长

6 months

期刊介绍： The Journal of Medical Primatology publishes research on non-human primates as models to study, prevent, and/or treat human diseases; subjects include veterinary medicine; morphology, physiology, reproductive biology, central nervous system, and cardiovascular diseases; husbandry, handling, experimental methodology, and management of non-human primate colonies and laboratories; non-human primate wildlife management; and behaviour and sociology as related to medical conditions and captive non-human primate needs. Published material includes: Original Manuscripts - research results; Case Reports - scientific documentation of a single clinical study; Short Papers - case histories, methodologies, and techniques of particular interest; Letters to the Editor - opinions, controversies and sporadic scientific observations; Perspectives – opinion piece about existing research on a particular topic; Minireviews – a concise review of existing literature; Book Reviews by invitation; Special Issues containing selected papers from specialized meetings; and Editorials and memoriams authored by the Editor-in-Chief.