Histological Features of IgA Nephropathy in Pediatrics and the Magnitude of the Disease in Saudi Children.

IF 1.3 Q3 PEDIATRICS
International Journal of Pediatrics Pub Date : 2023-04-03 eCollection Date: 2023-01-01 DOI:10.1155/2023/3466726
Reem A Al Zahrani
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引用次数: 0

Abstract

Objectives: This review addresses the microscopic features of immunoglobulin A nephropathy (IgA nephropathy), its prognostic variables in children, and measures to which extent these features and variables differ from adults. Furthermore, it describes the extent of this disease process among children in Saudi Arabia and the rest of the Arab countries and compares it with the data from the West and the Far East.

Method: All the original work described the histological features of pediatric IgA nephropathy, and studies involved in developing the prognostic classification of IgA nephropathy, Oxford Classification, were reviewed. Moreover, the studies describing the crescent prevalence and outcome in pediatric IgA nephropathy in addition to thrombotic microangiopathy association were studied. National studies describing the prevalence of pediatric IgA nephropathy and pediatric crescentic glomerulonephritis were tracked with an overview of the regional data from the rest of the Arab world.

Results: IgA nephropathy in children showed more glomerular proliferative changes and less glomerular vascular and tubule-interstitial chronic injury compared to adults. The reference study that described the association between thrombotic microangiopathy and IgA nephropathy did not include the pediatric age group. Moreover, it was found that the data from the Middle East was not encountered in developing the original and updated IgA nephropathy Oxford Classification. Furthermore, the prevalence of IgA nephropathy in children is described in the regional literature, but its histological features were not well detailed. Finally, the percentage of crescentic glomerulonephritis (GN) due to IgA nephropathy is less in our country compared to the West and concords with the Far East findings.

Conclusion: A well-designed regional study addressing IgA nephropathy in Middle East children with a focus on histological features, association with crescent, and thrombotic microangiopathy and challenging the validity of the updated IgA nephropathy Oxford Classification is recommended.

IgA肾病在儿科的组织学特征和沙特儿童的疾病程度。
目的:本文综述了免疫球蛋白A肾病(IgA肾病)的微观特征、儿童的预后变量,以及这些特征和变量与成人的差异程度。此外,它描述了沙特阿拉伯和其他阿拉伯国家儿童的这种疾病过程的程度,并将其与西方和远东的数据进行了比较,审查。此外,还研究了儿童IgA肾病新月形患病率和结果以及血栓性微血管病的相关性。对描述儿童IgA肾病和儿童新月体肾小球肾炎患病率的国家研究进行了跟踪,并对阿拉伯世界其他地区的区域数据进行了概述。结果:与成人相比,儿童IgA肾病表现出更多的肾小球增殖性变化,肾小球血管和小管间质慢性损伤更少。描述血栓性微血管病与IgA肾病之间关系的参考研究不包括儿童年龄组。此外,研究发现,在制定原始和更新的IgA肾病牛津分类法时,没有遇到来自中东的数据。此外,IgA肾病在儿童中的患病率在地区文献中有描述,但其组织学特征没有得到很好的详细描述。最后,与西方相比,我国IgA肾病引起的新月体肾小球肾炎(GN)的百分比较低,这与远东的研究结果一致。结论:建议对中东儿童IgA肾病进行一项精心设计的区域研究,重点关注组织学特征、与新月形和血栓性微血管病的关系,并对更新的IgA肾病牛津分类的有效性提出质疑。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.90
自引率
0.00%
发文量
0
审稿时长
4 weeks
期刊介绍: International Journal of Pediatrics is a peer-reviewed, open access journal that publishes original researcharticles, review articles, and clinical studies in all areas of pediatric research. The journal accepts submissions presented as an original article, short communication, case report, review article, systematic review, or letter to the editor.
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