Altered intrinsic functional network connectivity is associated with impulsivity and emotion dysregulation in drug-naïve young patients with borderline personality disorder.

IF 4 2区 医学 Q1 PSYCHIATRY
Wanyi Cao, Ying Liu, Mingtian Zhong, Haiyan Liao, Sainan Cai, Jun Chu, Shuxin Zheng, Changlian Tan, Jinyao Yi
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Abstract

Background: Despite impulse control and emotion regulation being altered in borderline personality disorder (BPD), the specific mechanism of these clinical features remains unclear. This study investigated the functional connectivity (FC) abnormalities within- and between- default mode network (DMN), salience network (SN), and central executive network (CEN) in BPD, and examined the association between aberrant FC and clinical features. We aimed to explore whether the abnormal large-scale networks underlie the pathophysiology of impulsivity and emotion dysregulation in BPD.

Methods: Forty-one young, drug-naïve patients with BPD (24.98 ± 3.12 years, 20 males) and 42 healthy controls (HCs; 24.74 ± 1.29 years, 17 males) were included in resting-state functional magnetic resonance imaging analyses. Independent component analysis was performed to extract subnetworks of the DMN, CEN, and SN. Additionally, partial correlation was performed to explore the association between brain imaging variables and clinical features in BPD.

Results: Compared with HCs, BPD showed significant decreased intra-network FC of right medial prefrontal cortex in the anterior DMN and of right angular gyrus in the right CEN. Intra-network FC of right angular gyrus in the anterior DMN was significantly negatively correlated with attention impulsivity in BPD. The patients also showed decreased inter-network FC between the posterior DMN and left CEN, which was significantly negatively correlated with emotion dysregulation.

Conclusion: These findings suggest that impaired intra-network FC may underlie the neurophysiological mechanism of impulsivity, and abnormal inter-network FC may elucidate the neurophysiological mechanism of emotion dysregulation in BPD.

Abstract Image

Abstract Image

drug-naïve年轻边缘型人格障碍患者的内在功能网络连接改变与冲动和情绪失调有关。
背景:尽管边缘型人格障碍(BPD)患者的冲动控制和情绪调节发生了改变,但这些临床特征的具体机制尚不清楚。本研究探讨了BPD中默认模式网络(DMN)、突出网络(SN)和中央执行网络(CEN)内部和之间的功能连接(FC)异常,并探讨了FC异常与临床特征的关系。我们的目的是探讨这种异常的大规模网络是否在BPD患者冲动和情绪失调的病理生理基础上起作用。方法:41例年轻(drug-naïve) BPD患者(24.98±3.12岁,男性20例)和42例健康对照(hc;(24.74±1.29)岁,男性17例,静息状态磁共振成像分析。进行独立分量分析,提取DMN、CEN和SN的子网。此外,采用部分相关方法探讨脑成像变量与BPD临床特征之间的关系。结果:与hc相比,BPD显示DMN前部右侧内侧前额叶皮层和CEN右侧角回的网络内FC明显减少。DMN前部右侧角回网络内FC与BPD患者的注意冲动性呈显著负相关。患者还表现出DMN后部与左侧CEN之间的网络间FC减少,与情绪失调呈显著负相关。结论:网络内FC受损可能是冲动性神经生理机制的基础,网络间FC异常可能阐明BPD情绪失调的神经生理机制。
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来源期刊
CiteScore
6.00
自引率
9.80%
发文量
30
审稿时长
28 weeks
期刊介绍: Borderline Personality Disorder and Emotion Dysregulation provides a platform for researchers and clinicians interested in borderline personality disorder (BPD) as a currently highly challenging psychiatric disorder. Emotion dysregulation is at the core of BPD but also stands on its own as a major pathological component of the underlying neurobiology of various other psychiatric disorders. The journal focuses on the psychological, social and neurobiological aspects of emotion dysregulation as well as epidemiology, phenomenology, pathophysiology, treatment, neurobiology, genetics, and animal models of BPD.
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