Mechanisms of RNA export and nuclear retention.

IF 6.4 2区 生物学 Q1 CELL BIOLOGY
Misbah Khan, Shuai Hou, Mo Chen, Haixin Lei
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引用次数: 7

Abstract

With the identification of huge amount of noncoding RNAs in recent years, the concept of RNA localization has extended from traditional mRNA export to RNA export of mRNA and ncRNA as well as nuclear retention of ncRNA. This review aims to summarize the recent findings from studies on the mechanisms of export of different RNAs and nuclear retention of some lncRNAs in higher eukaryotes, with a focus on splicing-dependent TREX recruitment for the export of spliced mRNA and the sequence-dependent mechanism of mRNA export in the absence of splicing. In addition, evidence to support the involvement of m6 A modification in RNA export with the coordination between the methylase complex and TREX complex as well as sequence-dependent nuclear retention of lncRNA is recapitulated. Finally, a model of sequence-dependent RNA localization is proposed along with the many questions that remain to be answered. This article is categorized under: RNA Export and Localization > RNA Localization RNA Export and Localization > Nuclear Export/Import.

RNA输出和核保留机制。
近年来,随着大量非编码RNA的发现,RNA定位的概念从传统的mRNA输出扩展到mRNA和ncRNA的RNA输出以及ncRNA的核保留。本文综述了高等真核生物中不同rna的输出机制和一些lncrna的核保留的最新研究成果,重点介绍了剪接依赖性TREX招募对剪接mRNA输出的影响,以及无剪接时mRNA输出的序列依赖性机制。此外,本文还概述了支持m6 A修饰参与RNA输出与甲基化酶复合物和TREX复合物之间的协调以及lncRNA序列依赖的核保留的证据。最后,提出了一个序列依赖的RNA定位模型以及许多有待回答的问题。本文分类如下:RNA出口和本地化> RNA本地化> RNA出口和本地化>核出口/进口。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
14.80
自引率
4.10%
发文量
67
审稿时长
6-12 weeks
期刊介绍: WIREs RNA aims to provide comprehensive, up-to-date, and coherent coverage of this interesting and growing field, providing a framework for both RNA experts and interdisciplinary researchers to not only gain perspective in areas of RNA biology, but to generate new insights and applications as well. Major topics to be covered are: RNA Structure and Dynamics; RNA Evolution and Genomics; RNA-Based Catalysis; RNA Interactions with Proteins and Other Molecules; Translation; RNA Processing; RNA Export/Localization; RNA Turnover and Surveillance; Regulatory RNAs/RNAi/Riboswitches; RNA in Disease and Development; and RNA Methods.
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