Novel formulations for topical delivery of tranexamic acid: assessing the need of epidermal targeting for hyperpigmentation disorders.

IF 5 2区医学 Q1 PHARMACOLOGY & PHARMACY

Expert Opinion on Drug Delivery Pub Date : 2023-06-01 DOI:10.1080/17425247.2023.2206645

Piyush Verma, Khushwant S Yadav

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引用次数: 3

Abstract

Introduction: Tranexamic acid is used for the treatment of hyperpigmentation, and the topical route is the most favorable route for its administration. Tranexamic acid lowers plasmin and tyrosinase, which reduces melanin and skin hyperpigmentation. Low penetration through the outer layer of skin and low availability at target melanocyte cells limit tranexamic acid topical administration. Different novel delivery systems like liposomes, microneedles, topical beads, and microparticles can help in overcoming these limitations.

Areas covered: The mechanism of action of tranexamic acid and novel delivery systems for its topical delivery have been discussed. Further, patents related to the topical delivery of tranexamic acid and clinical trials undertaken to analyze their potential have been discussed.

Expert opinion: Targeting tranexamic acid in the epidermal layer makes more amount of drug available for action on melanocytes, the target site for tranexamic acid. Novel drug delivery formulations like liposomes, solid lipid nanoparticles, nano-lipidic carriers, and topical beads have the potential of achieving epidermal targeting. Epidermal targeting of tranexamic acid can help in the superior delivery of the drug, making its topical treatment more efficient.

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局部递送氨甲环酸的新配方:评估表皮靶向治疗色素沉着症的需要。

简介:氨甲环酸用于治疗色素沉着，外用途径是其最有利的给药途径。氨甲环酸能降低纤溶蛋白和酪氨酸酶，从而减少黑色素和皮肤色素沉着。透过皮肤外层的渗透性低，在目标黑素细胞中的有效性低，限制了氨甲环酸的局部施用。不同的新型给药系统，如脂质体、微针、局部微珠和微颗粒，可以帮助克服这些限制。研究领域:讨论了氨甲环酸的作用机制和局部给药的新型给药系统。此外，还讨论了与局部给药氨甲环酸相关的专利以及为分析其潜力而进行的临床试验。专家意见:以表皮层的氨甲环酸为靶点，可使更多的药物作用于氨甲环酸的靶点黑素细胞。新型药物递送制剂如脂质体、固体脂质纳米颗粒、纳米脂质载体和局部微球具有实现表皮靶向的潜力。氨甲环酸的表皮靶向可以帮助药物更好地传递，使其局部治疗更有效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Expert Opinion on Drug Delivery 医学-药学

CiteScore

11.10

自引率

3.00%

发文量

104

审稿时长

3 months

期刊介绍： Expert Opinion on Drug Delivery (ISSN 1742-5247 [print], 1744-7593 [electronic]) is a MEDLINE-indexed, peer-reviewed, international journal publishing review articles covering all aspects of drug delivery research, from initial concept to potential therapeutic application and final relevance in clinical use. Each article is structured to incorporate the author’s own expert opinion on the scope for future development.