Bordetella bronchiseptica and Bordetella pertussis: Similarities and Differences in Infection, Immuno-Modulation, and Vaccine Considerations.

IF 19 1区 医学 Q1 MICROBIOLOGY
Clinical Microbiology Reviews Pub Date : 2023-09-21 Epub Date: 2023-06-12 DOI:10.1128/cmr.00164-22
Beatriz Miguelena Chamorro, Karelle De Luca, Gokul Swaminathan, Stéphanie Longet, Egbert Mundt, Stéphane Paul
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引用次数: 0

Abstract

Bordetella pertussis and Bordetella bronchiseptica belong to the genus Bordetella, which comprises 14 other species. B. pertussis is responsible for whooping cough in humans, a severe infection in children and less severe or chronic in adults. These infections are restricted to humans and currently increasing worldwide. B. bronchiseptica is involved in diverse respiratory infections in a wide range of mammals. For instance, the canine infectious respiratory disease complex (CIRDC), characterized by a chronic cough in dogs. At the same time, it is increasingly implicated in human infections, while remaining an important pathogen in the veterinary field. Both Bordetella can evade and modulate host immune responses to support their persistence, although it is more pronounced in B. bronchiseptica infection. The protective immune responses elicited by both pathogens are comparable, while there are important characteristics in the mechanisms that differ. However, B. pertussis pathogenesis is more difficult to decipher in animal models than those of B. bronchiseptica because of its restriction to humans. Nevertheless, the licensed vaccines for each Bordetella are different in terms of formulation, route of administration and immune responses induced, with no known cross-reaction between them. Moreover, the target of the mucosal tissues and the induction of long-lasting cellular and humoral responses are required to control and eliminate Bordetella. In addition, the interaction between both veterinary and human fields are essential for the control of this genus, by preventing the infections in animals and the subsequent zoonotic transmission to humans.

支气管败血博德菌和百日咳博德菌:感染、免疫调节和疫苗注意事项的异同。
百日咳博德特氏菌和支气管败血博德氏菌属于博德特菌属,包括其他14种。B.百日咳是引起人类百日咳的原因,百日咳是儿童的严重感染,成人的病情较轻或较慢性。这些感染仅限于人类,目前在全球范围内不断增加。B.支气管败血症与多种哺乳动物的多种呼吸道感染有关。例如,犬传染性呼吸道疾病复合体(CIRDC),其特征是犬的慢性咳嗽。与此同时,它越来越多地与人类感染有关,同时在兽医领域仍然是一种重要的病原体。博德特菌都可以逃避和调节宿主免疫反应,以支持其持久性,尽管它在支气管败血病感染中更为明显。两种病原体引发的保护性免疫反应具有可比性,但其机制有重要特征不同。然而,百日咳杆菌的发病机制在动物模型中比支气管败血病的发病机制更难解读,因为它仅限于人类。尽管如此,每种博德氏菌的许可疫苗在配方、给药途径和诱导的免疫反应方面都不同,它们之间没有已知的交叉反应。此外,需要粘膜组织的靶点以及诱导持久的细胞和体液反应来控制和消除博德氏菌。此外,兽医和人类领域之间的相互作用对于控制该属至关重要,可以防止动物感染和随后的人畜共患传播给人类。
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来源期刊
Clinical Microbiology Reviews
Clinical Microbiology Reviews 医学-微生物学
CiteScore
54.20
自引率
0.50%
发文量
38
期刊介绍: Clinical Microbiology Reviews (CMR) is a journal that primarily focuses on clinical microbiology and immunology.It aims to provide readers with up-to-date information on the latest developments in these fields.CMR also presents the current state of knowledge in clinical microbiology and immunology.Additionally, the journal offers balanced and thought-provoking perspectives on controversial issues in these areas.
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